Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research.

Objective: Oral supplementation with iron is a standard intervention for treating or preventing iron deficiency with or without anemia. Over the last few decades, various forms of oral iron have been developed to improve treatment tolerability and iron bioavailability. In this review, we gathered research data regarding the use of iron protein succinylate since it was first marketed in the 1980s.

Hsp60, Hsp70 and Hsp90

Methods: Electronic databases-PubMed and the Cochrane Library-were searched for studies published up to March 2019. Clinical or observational studies reporting data on the tolerability of oral iron protein succinylate were included.

Results were statistically described to evaluate and compare the efficacy and safety of iron protein succinylate with the comparators under study.Results: Iron protein succinylate was investigated in 54 studies: 38 randomized clinical trials and 16 observational studies, with a total of 8,454 subjects. Of them, 8,142 were included in the efficacy analysis: patients were divided into three population subtypes: general (n = 1,899), gynecological/obstetric (n = 5,283), and pediatric (n = 960). In total, 6,450 patients received iron protein succinylate, experiencing a significant change in hemoglobin and ferritin in all populations. The change in all parameters was similar or higher with iron protein succinylate compared to other iron treatments evaluated. Overall, study groups receiving iron protein succinylate reported the lowest rate of adverse events.

Conclusions: Although all iron treatments analyzed are effective and safe, our results suggest that iron protein succinylate may be an excellent choice to treat iron deficiency and anemia due to its superior effectiveness and tolerability.

As the research community strives to make published research ever more transparent and reliable, the quality of reagents used comes into focus. One category of such reagents that requires much stricter quality controls are recombinant proteins. Examples of typical quality issues with recombinant proteins will be presented, along with some results as to how this affects the reliability of the intended downstream application.

One very problematic issue to be presented is aggregation and its effect on protein-protein affinity measurements. In order to improve the reliability and reproducibility of data using purified proteins in life science research, a group of professionals involved in protein purification and protein characterization/molecular biophysics from both the ARBRE-MOBIEU (Association of Resources for Biophysical research in Europe MOlecular BIophysics in EUrope) and P4EU (Protein Production and Purification Partnership in Europe) networks have drafted guidelines for improved quality control (QC).

Vitamin A-d5 Acetate
MBS6106493-5x1mg 5x1mg
EUR 3630

Vitamin A-d5 Acetate
V676002 10mg
EUR 523
Description: 1217219-62-9

Biotin (Vitamin B7 or Vitamin H)
MBS438174-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Biotin (Vitamin B7 or Vitamin H)
MBS438174-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Biotin (Vitamin B7 or Vitamin H)
MBS438174-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Biotin (Vitamin B7 or Vitamin H)
MBS438174-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Biotin (Vitamin B7 or Vitamin H)
MBS438174-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Biotin (Vitamin B7 or Vitamin H)
MBS4380419-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Biotin (Vitamin B7 or Vitamin H)
MBS4380419-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Biotin (Vitamin B7 or Vitamin H)
MBS4380419-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Biotin (Vitamin B7 or Vitamin H)
MBS4380419-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Biotin (Vitamin B7 or Vitamin H)
MBS4380419-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Biotin (Vitamin B7 or Vitamin H)
MBS438338-002mgWithBSAAzideat02mgmL 0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230

Biotin (Vitamin B7 or Vitamin H)
MBS438338-01mgWithBSAAzideat02mgmL 0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405

Biotin (Vitamin B7 or Vitamin H)
MBS438338-01mgWithoutBSAAzideat1mgmL 0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405

Biotin (Vitamin B7 or Vitamin H)
MBS438338-5x01mgWithBSAAzideat02mgmL 5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725

Biotin (Vitamin B7 or Vitamin H)
MBS438338-5x01mgWithoutBSAAzideat1mgmL 5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725

Biotin (Vitamin B7, Vitamin H) (AP)
MBS6123886-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (AP)
MBS6123886-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (PE)
MBS6123891-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (PE)
MBS6123891-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (AP)
MBS6122543-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (AP)
MBS6122543-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (PE)
MBS6122548-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (PE)
MBS6122548-5x01mL 5x0.1mL
EUR 4050

Vitamin C（Vitamin C）ELISA Kit
QY-E160029 96T
EUR 480

Biotin (Vitamin B7, Vitamin H) (APC)
MBS6123887-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (APC)
MBS6123887-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (HRP)
MBS6123890-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (HRP)
MBS6123890-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (APC)
MBS6122544-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (APC)
MBS6122544-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (HRP)
MBS6122547-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (HRP)
MBS6122547-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (FITC)
MBS6123889-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (FITC)
MBS6123889-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (FITC)
MBS6122546-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (FITC)
MBS6122546-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (Biotin)
MBS6123888-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (Biotin)
MBS6123888-5x01mL 5x0.1mL
EUR 4050

Biotin (Vitamin B7, Vitamin H) (Biotin)
MBS6122545-01mL 0.1(mL
EUR 935

Biotin (Vitamin B7, Vitamin H) (Biotin)
MBS6122545-5x01mL 5x0.1mL
EUR 4050

Riboflavin (Vitamin B2, Lactoflavin, Vitamin G)
MBS641079-100g 100g
EUR 220

Riboflavin (Vitamin B2, Lactoflavin, Vitamin G)
MBS641079-1kg 1kg
EUR 1180

Riboflavin (Vitamin B2, Lactoflavin, Vitamin G)
MBS641079-25g 25g
EUR 135

Riboflavin (Vitamin B2, Lactoflavin, Vitamin G)
MBS641079-500g 500g
EUR 715

Riboflavin (Vitamin B2, Lactoflavin, Vitamin G)
MBS641079-5x1kg 5x1kg
EUR 5200

Vitamin B2
36321-32 25G
EUR 23.8

Vitamin B2
36321-74 5G
EUR 13.3

Vitamin B2
36322-51 1G
EUR 14.7

Vitamin D2
36402-01 1G
EUR 39.9

Vitamin D2
36402-14 5G
EUR 126

Vitamin D3
36403-04 100MG
EUR 19.95

Vitamin D3
36403-91 1G
EUR 80.5

Vitamin K1
36404-81 1G
EUR 21.7

Vitamin K1
36404-94 5G
EUR 65.1

Vitamin K3
36405-42 25G
EUR 51.8

Vitamin K3
36405-71 1G
EUR 17.85

Vitamin K3
36405-84 5G
EUR 23.45

Vitamin P
36407-64 5G
EUR 19.25

Vitamin U
36408-54 5G
EUR 18.9

Vitamin E
CMS185-50G 1 unit
EUR 40.82
Description: Vitamin E

Vitamin D3
CMS334-10G 1 unit
EUR 204.76
Description: Vitamin D3

Vitamin B2
abx188930-5g 5 g
EUR 243.6

Vitamin A
B2456-250 each
EUR 314.4

Vitamin A
B2456-50 each
EUR 157.2

Vitamin E
B6145-100 100 mg
EUR 235.2

Vitamin E
B6145-500 500 mg
EUR 555.6

Vitamin C
B2064-1000 1g
EUR 40
Description: Others|Others

Vitamin C
B2064-5.1 10 mM (in 1mL DMSO)
EUR 44
Description: Others|Others

Vitamin C
B2064-50 50 mg
EUR 153.6
Description: Ascorbic acid is a naturally occurring organic compound with antioxidant properties.

Vitamin D3
B2065-5000 5 g
EUR 62.4
Description: Vitamin D Related|VD/VDR

Vitamin B2
AT206 1mg
EUR 1336.8

Vitamin D2
20-abx184475
  • Ask for price
  • Ask for price
  • Ask for price
  • 5 g
  • 10 g
  • 25 g

Vitamin D3
20-abx185612
  • Ask for price
  • Ask for price
  • 1 g
  • 10 g

Vitamin B2
AG206 1 mg
EUR 627.6

Vitamin D4
HY-75958 1mg
EUR 3463.26
Description: Vitamin D4 (22-Dihydroergocalciferol) is a Vitamin D derived from fungi. The precursor of Vitamin D4 is 22,23-dihydroergosterol[1].

Vitamin D2
HY-76542 10mM/1mL
EUR 54.11
Description: Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].

Vitamin K4
HY-B1508 1g
EUR 207.6

Vitamin K
HY-B2172 500mg
EUR 258

Vitamin K1
HY-N0684 500mg
EUR 129.6

Vitamin D3
HY-15398 100mg
EUR 292.21
Description: Vitamin D3 (Cholecalciferol; Colecalciferol) is a naturally occuring form of vitamin D. Vitamin D3 induces cell differentiation and prevents proliferation of cancer cells.

Vitamin K2
HY-109569 10 mg
EUR 324.68
Description: Vitamin K2 is an endogenous metabolite.

Vitamin K3
GV3614 25g
EUR 29.04

Vitamin K3
GV3614-25 25
EUR 31.7

Vitamin K3
GV3614-25G 25 g
EUR 74.4

Vitamin K1
GV4612 1g
EUR 39.85

Vitamin K1
GV4612-1 1
EUR 43.5

Vitamin K1
GV4612-1G 1 g
EUR 88.8

Vitamin D2
GV6132 1g
EUR 165.51

Vitamin D2
GV6132-1 1
EUR 52.8

Vitamin D2
GV6132-1G 1 g
EUR 93.6

Vitamin D2
GV6132-5 5
EUR 180.8

Vitamin D2
GV6132-5G 5 g
EUR 237.6

Vitamin K2
GV6200 1g
EUR 260.82

Vitamin K2
GV6200-1 1
EUR 284.8

Vitamin D2
MBS3604686-10mg 10mg
EUR 195

Vitamin D2
MBS3604686-200mg 200mg
EUR 210

Vitamin D2
MBS3604686-50mg 50mg
EUR 195

Vitamin D2
MBS3604686-5x200mg 5x200mg
EUR 630

Vitamin E
MBS3605181-100mg 100mg
EUR 200

Vitamin E
MBS3605181-5x100mg 5x100mg
EUR 580

Vitamin D3
MBS3605592-50mg 50mg
EUR 200

Vitamin D3
MBS3605592-5x50mg 5x50mg
EUR 580

Vitamin D4
MBS3840981-10mg 10mg
EUR 1185

Vitamin D4
MBS3840981-50mg 50mg
EUR 3275

Vitamin D4
MBS3840981-5mg 5mg
EUR 725

Vitamin D4
MBS3840981-5x50mg 5x50mg
EUR 14725

Vitamin K1
MBS3606154-100mg 100mg
EUR 200

Vitamin K1
MBS3606154-50mg 50mg
EUR 195

Vitamin K1
MBS3606154-5x100mg 5x100mg
EUR 580

Vitamin K1
MBS3842319-1g 1g
EUR 160

Vitamin K1
MBS3842319-5x1g 5x1g
EUR 715

Vitamin D2
MBS3841771-500mg 500mg
EUR 135

Vitamin D2
MBS3841771-5x500mg 5x500mg
EUR 600

Vitamin A
MBS3842470-100mg 100mg
EUR 140

Vitamin A
MBS3842470-500mg 500mg
EUR 245

Vitamin A
MBS3842470-5x500mg 5x500mg
EUR 1105

Vitamin K1
MBS575930-100mg 100mg
EUR 130

Vitamin K1
MBS575930-1g 1g
EUR 160

Vitamin K1
MBS575930-500mg 500mg
EUR 145

Vitamin K1
MBS575930-5x1g 5x1g
EUR 560

Vitamin D4
MBS5756133-10mg 10mg
EUR 855

Vitamin D4
MBS5756133-1mg 1mg
EUR 210

Vitamin D4
MBS5756133-50mg 50mg
EUR 2415

Vitamin D4
MBS5756133-5mg 5mg
EUR 545

Vitamin D4
MBS5756133-5x50mg 5x50mg
EUR 10715

Vitamin E
MBS575696-100mg 100mg
EUR 135

Vitamin E
MBS575696-200mg 200mg
EUR 150

Vitamin E
MBS575696-25mg 25mg
EUR 125

Vitamin E
MBS575696-500mg 500mg
EUR 155

Vitamin E
MBS575696-50mg 50mg
EUR 135

Vitamin B6
MBS5750288-1mg 1mg
EUR 145

Vitamin B6
MBS5750288-5x1mg 5x1mg
EUR 500

Vitamin K
MBS5772064-10mg 10mg
EUR 175

Vitamin K
MBS5772064-25mg 25mg
EUR 215

Vitamin K
MBS5772064-5mg 5mg
EUR 150

Vitamin D2
MBS577258-1g 1g
EUR 145

Vitamin D2
MBS577258-500mg 500mg
EUR 145

Vitamin D2
MBS577258-5x1g 5x1g
EUR 505

Vitamin D3
MBS641071-1g 1g
EUR 500

Vitamin D3
MBS641071-5x1g 5x1g
EUR 2090

Vitamin E
TB02699 4X20mg
EUR 321.6

Vitamin C
TBW00996 100mg Ask for price
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