Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research.

Objective: Oral supplementation with iron is a standard intervention for treating or preventing iron deficiency with or without anemia. Over the last few decades, various forms of oral iron have been developed to improve treatment tolerability and iron bioavailability. In this review, we gathered research data regarding the use of iron protein succinylate since it was first marketed in the 1980s.

 Hsp60, Hsp70 and Hsp90

Methods: Electronic databases-PubMed and the Cochrane Library-were searched for studies published up to March 2019. Clinical or observational studies reporting data on the tolerability of oral iron protein succinylate were included.

Results were statistically described to evaluate and compare the efficacy and safety of iron protein succinylate with the comparators under study.Results: Iron protein succinylate was investigated in 54 studies: 38 randomized clinical trials and 16 observational studies, with a total of 8,454 subjects. Of them, 8,142 were included in the efficacy analysis: patients were divided into three population subtypes: general (n = 1,899), gynecological/obstetric (n = 5,283), and pediatric (n = 960). In total, 6,450 patients received iron protein succinylate, experiencing a significant change in hemoglobin and ferritin in all populations. The change in all parameters was similar or higher with iron protein succinylate compared to other iron treatments evaluated. Overall, study groups receiving iron protein succinylate reported the lowest rate of adverse events.

Conclusions: Although all iron treatments analyzed are effective and safe, our results suggest that iron protein succinylate may be an excellent choice to treat iron deficiency and anemia due to its superior effectiveness and tolerability.

As the research community strives to make published research ever more transparent and reliable, the quality of reagents used comes into focus. One category of such reagents that requires much stricter quality controls are recombinant proteins. Examples of typical quality issues with recombinant proteins will be presented, along with some results as to how this affects the reliability of the intended downstream application.

One very problematic issue to be presented is aggregation and its effect on protein-protein affinity measurements. In order to improve the reliability and reproducibility of data using purified proteins in life science research, a group of professionals involved in protein purification and protein characterization/molecular biophysics from both the ARBRE-MOBIEU (Association of Resources for Biophysical research in Europe MOlecular BIophysics in EUrope) and P4EU (Protein Production and Purification Partnership in Europe) networks have drafted guidelines for improved quality control (QC).

Biotin / Vitamin B7 / Vitamin H Antibody

V8868-100UG 100ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V8868-20UG 20ug
EUR 186.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V8868SAF-100UG 100ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9113-100UG 100 ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9113-20UG 20 ug
EUR 186.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9113SAF-100UG 100 ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V3649-100UG 100 ug
EUR 349.3
Description: This mAb recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V3649-20UG 20 ug
EUR 153.3
Description: This mAb recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V3649IHC-7ML 7 ml
EUR 349.3
Description: This mAb recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V3649SAF-100UG 100 ug
EUR 349.3
Description: This mAb recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V2319-100UG 100 ug
EUR 424.15
Description: This antibody recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. The mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V2319-20UG 20 ug
EUR 186.15
Description: This antibody recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. The mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V2319SAF-100UG 100 ug
EUR 424.15
Description: This antibody recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. The mAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9352-100UG 100ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9352-20UG 20ug
EUR 186.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9352SAF-100UG 100ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9363-100UG 100ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9363-20UG 20ug
EUR 186.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Biotin / Vitamin B7 / Vitamin H Antibody

V9363SAF-100UG 100ug
EUR 424.15
Description: It recognizes both the free and protein-conjugated (either soluble or cell bound) form of biotin. This MAb is highly specific to biotin and shows no cross-reaction with other structurally related compounds. It has a very high affinity for biotin and is excellent for use in various amplification techniques. In some applications, localization of biotinylated probes with avidin produces unacceptably high background staining. Anti-biotin antibody may be substituted to decrease this noise.

Vitamin B2

36321-32 25G
EUR 23.8

Vitamin B2

36321-74 5G
EUR 13.3

Vitamin B2

36322-51 1G
EUR 14.7

Vitamin D2

36402-01 1G
EUR 39.9

Vitamin D2

36402-14 5G
EUR 126

Vitamin D3

36403-04 100MG
EUR 19.95

Vitamin D3

36403-91 1G
EUR 80.5

Vitamin K1

36404-81 1G
EUR 21.7

Vitamin K1

36404-94 5G
EUR 65.1

Vitamin K3

36405-42 25G
EUR 51.8

Vitamin K3

36405-71 1G
EUR 17.85

Vitamin K3

36405-84 5G
EUR 23.45

Vitamin P

36407-64 5G
EUR 19.25

Vitamin U

36408-54 5G
EUR 18.9

Vitamin E

B6145-100 100 mg
EUR 235.2

Vitamin E

B6145-500 500 mg
EUR 555.6

Vitamin C

B2064-1000 1g
EUR 38
Description: water soluble vitamin

Vitamin C

B2064-5.1 10 mM (in 1mL DMSO)
EUR 40
Description: water soluble vitamin

Vitamin C

B2064-50 50 mg
EUR 153.6
Description: Ascorbic acid is a naturally occurring organic compound with antioxidant properties.

Vitamin D3

B2065-5000 5 g
EUR 62
Description: Fat-soluble secosteroids

Vitamin B2

AT206 1mg
EUR 1336.8

Vitamin A

B2456-250 each
EUR 314.4

Vitamin A

B2456-50 each
EUR 157.2

Vitamin B2

AG206 1 mg
EUR 627.6

Vitamin D3

20-abx185612
  • Ask for price
  • Ask for price
  • 10 g
  • 1 g

Vitamin B2

abx188930-5g 5 g
EUR 243.6

Vitamin D2

20-abx184475
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 g
  • 25 g
  • 5 g

Vitamin K3

GV3614-25 25
EUR 31.7

Vitamin K3

GV3614-25G 25 g
EUR 74.4

Vitamin K1

GV4612-1 1
EUR 43.5

Vitamin K1

GV4612-1G 1 g
EUR 88.8

Vitamin D2

GV6132-1 1
EUR 52.8

Vitamin D2

GV6132-1G 1 g
EUR 93.6

Vitamin D2

GV6132-5 5
EUR 180.8

Vitamin D2

GV6132-5G 5 g
EUR 237.6

Vitamin K2

GV6200-1 1
EUR 284.8

Vitamin D4

T19602-10mg 10mg Ask for price
Description: Vitamin D4

Vitamin D4

T19602-1g 1g Ask for price
Description: Vitamin D4

Vitamin D4

T19602-1mg 1mg Ask for price
Description: Vitamin D4

Vitamin D4

T19602-50mg 50mg Ask for price
Description: Vitamin D4

Vitamin D4

T19602-5mg 5mg Ask for price
Description: Vitamin D4

Vitamin K

T19603-10mg 10mg Ask for price
Description: Vitamin K

Vitamin K

T19603-1g 1g Ask for price
Description: Vitamin K

Vitamin K

T19603-1mg 1mg Ask for price
Description: Vitamin K

Vitamin K

T19603-50mg 50mg Ask for price
Description: Vitamin K

Vitamin K

T19603-5mg 5mg Ask for price
Description: Vitamin K

Vitamin K4

T2570-10mg 10mg Ask for price
Description: Vitamin K4

Vitamin K4

T2570-1g 1g Ask for price
Description: Vitamin K4

Vitamin K4

T2570-1mg 1mg Ask for price
Description: Vitamin K4

Vitamin K4

T2570-50mg 50mg Ask for price
Description: Vitamin K4

Vitamin K4

T2570-5mg 5mg Ask for price
Description: Vitamin K4

Vitamin K2

T2336-10mg 10mg Ask for price
Description: Vitamin K2

Vitamin K2

T2336-1g 1g Ask for price
Description: Vitamin K2

Vitamin K2

T2336-1mg 1mg Ask for price
Description: Vitamin K2

Vitamin K2

T2336-50mg 50mg Ask for price
Description: Vitamin K2

Vitamin K2

T2336-5mg 5mg Ask for price
Description: Vitamin K2

Vitamin C

TBW00996 100mg Ask for price

Vitamin K2

TBW01027 20mg Ask for price

Vitamin E

TB02699 4X20mg
EUR 321.6

Vitamin K1

TBZ2488 100mg Ask for price

VitaMin K5

TBZ2840 500mg Ask for price

Vitamin B6

T3O2784-10mg 10mg Ask for price
Description: Vitamin B6

Vitamin B6

T3O2784-1g 1g Ask for price
Description: Vitamin B6

Vitamin B6

T3O2784-1mg 1mg Ask for price
Description: Vitamin B6

Vitamin B6

T3O2784-50mg 50mg Ask for price
Description: Vitamin B6

Vitamin B6

T3O2784-5mg 5mg Ask for price
Description: Vitamin B6

Vitamin K

HY-B2172 500mg
EUR 258

Vitamin K1

HY-N0684 500mg
EUR 129.6

Vitamin D4

HY-75958 1mg
EUR 325.2

Vitamin D2

HY-76542 10mM/1mL
EUR 135.6

Vitamin K4

HY-B1508 1g
EUR 207.6

Vitamin D3

T1135-10mg 10mg Ask for price
Description: Vitamin D3

Vitamin D3

T1135-1g 1g Ask for price
Description: Vitamin D3

Vitamin D3

T1135-1mg 1mg Ask for price
Description: Vitamin D3

Vitamin D3

T1135-50mg 50mg Ask for price
Description: Vitamin D3

Vitamin D3

T1135-5mg 5mg Ask for price
Description: Vitamin D3

Vitamin K1

T1075-10mg 10mg Ask for price
Description: Vitamin K1

Vitamin K1

T1075-1g 1g Ask for price
Description: Vitamin K1

Vitamin K1

T1075-1mg 1mg Ask for price
Description: Vitamin K1

Vitamin K1

T1075-50mg 50mg Ask for price
Description: Vitamin K1

Vitamin K1

T1075-5mg 5mg Ask for price
Description: Vitamin K1

Vitamin D2

T1086-10mg 10mg Ask for price
Description: Vitamin D2

Vitamin D2

T1086-1g 1g Ask for price
Description: Vitamin D2

Vitamin D2

T1086-1mg 1mg Ask for price
Description: Vitamin D2

Vitamin D2

T1086-50mg 50mg Ask for price
Description: Vitamin D2

Vitamin D2

T1086-5mg 5mg Ask for price
Description: Vitamin D2

Vitamin E

CMS185-50G 1 unit
EUR 40.82
Description: Vitamin E

Vitamin D3

CMS334-10G 1 unit
EUR 204.76
Description: Vitamin D3

Vitamin B6

V805590 5g
EUR 75
Description: 8059-24-3

Vitamin D2

V676040 100mg
EUR 125
Description: 50-14-6

Vitamin D3

V676045 1g
EUR 97
Description: 67-97-0

Vitamin K3

V676130 2.5g
EUR 63
Description: 58-27-5

Vitamin D4

V680000 10mg
EUR 227
Description: 511-28-4

Vitamin K4

V680010 10g
EUR 75
Description: 573-20-6

Vitamin A

V02850 100MG
EUR 304.1

Vitamin D2

V03120 1G
EUR 286.47

Vitamin D3

V03130 1G
EUR 222.18

Vitamin H

V03240 1G
EUR 125.34

Vitamin K1

V03260 1G
EUR 404.96

Vitamin B12

11695-64 100MG
EUR 58.8

Vitamin B12

DEB12E01 96
EUR 265

Vitamin B12

36323-41 1G
EUR 50.4

Vitamin B12

36323-54 5G
EUR 200.2

Vitamin B12

36323-96 100MG
EUR 18.2

Vitamin B12

B2063-5.1 10 mM (in 1mL DMSO)
EUR 40
Description: water soluble vitamin

Vitamin B12

B2063-50 50 mg
EUR 153.6
Description: Vitamin B12

Vitamin B12

B2063-500 500mg
EUR 42
Description: water soluble vitamin

Vitamin B12

B2063-S Evaluation Sample
EUR 22
Description: water soluble vitamin

Vitamin B12

AT115 1mg
EUR 1641.6

Vitamin B12

AG115 1 mg
EUR 627.6

Vitamin B12

abx082092-1g 1 g
EUR 260.4

Vitamin B12

GE2859-1 1
EUR 39.4

Vitamin B12

GE2859-10 10
EUR 189.8

Vitamin B12

GE2859-10G 10 g
EUR 228

Vitamin B12

GE2859-1G 1 g
EUR 84

Vitamin B12

GE2859-25 25
EUR 379.6

Vitamin B12

GE2859-25G 25 g
EUR 399.6

Vitamin B12

GE2859-5 5
EUR 106.1

Vitamin B12

GE2859-5G 5 g
EUR 151.2

Vitamin B12

TBW00737 8XX20mg
EUR 328.8

Vitamin CK3

HY-16516 100mg
EUR 142.8

Vitamin B12

HY-B0315 500mg
EUR 142.8

Vitamin B15

T13960-10mg 10mg Ask for price
Description: Vitamin B15

Vitamin B15

T13960-1g 1g Ask for price
Description: Vitamin B15

Vitamin B15

T13960-1mg 1mg Ask for price
Description: Vitamin B15
Scroll to Top