Efficacy and tolerability of oral iron protein succinylate: a systematic review of three decades of research.

Objective: Oral supplementation with iron is a standard intervention for treating or preventing iron deficiency with or without anemia. Over the last few decades, various forms of oral iron have been developed to improve treatment tolerability and iron bioavailability. In this review, we gathered research data regarding the use of iron protein succinylate since it was first marketed in the 1980s.

 Hsp60, Hsp70 and Hsp90

Methods: Electronic databases-PubMed and the Cochrane Library-were searched for studies published up to March 2019. Clinical or observational studies reporting data on the tolerability of oral iron protein succinylate were included.

Results were statistically described to evaluate and compare the efficacy and safety of iron protein succinylate with the comparators under study.Results: Iron protein succinylate was investigated in 54 studies: 38 randomized clinical trials and 16 observational studies, with a total of 8,454 subjects. Of them, 8,142 were included in the efficacy analysis: patients were divided into three population subtypes: general (n = 1,899), gynecological/obstetric (n = 5,283), and pediatric (n = 960). In total, 6,450 patients received iron protein succinylate, experiencing a significant change in hemoglobin and ferritin in all populations. The change in all parameters was similar or higher with iron protein succinylate compared to other iron treatments evaluated. Overall, study groups receiving iron protein succinylate reported the lowest rate of adverse events.

Conclusions: Although all iron treatments analyzed are effective and safe, our results suggest that iron protein succinylate may be an excellent choice to treat iron deficiency and anemia due to its superior effectiveness and tolerability.

As the research community strives to make published research ever more transparent and reliable, the quality of reagents used comes into focus. One category of such reagents that requires much stricter quality controls are recombinant proteins. Examples of typical quality issues with recombinant proteins will be presented, along with some results as to how this affects the reliability of the intended downstream application.

One very problematic issue to be presented is aggregation and its effect on protein-protein affinity measurements. In order to improve the reliability and reproducibility of data using purified proteins in life science research, a group of professionals involved in protein purification and protein characterization/molecular biophysics from both the ARBRE-MOBIEU (Association of Resources for Biophysical research in Europe MOlecular BIophysics in EUrope) and P4EU (Protein Production and Purification Partnership in Europe) networks have drafted guidelines for improved quality control (QC).

Enalaprilat D5

HY-B0231AS 1mg
EUR 298

Phenindione D5

HY-B0325S 10mg
EUR 415

Triamterene D5

HY-B0575S 10mg
EUR 463

Doxylamine (D5 succinate)

HY-A0069S 5mg
EUR 1042

Enalapril (D5 maleate)

HY-B0331AS 5mg
EUR 1496

Ethacrynic acid - d5

B7726-1 1 mg
EUR 324

Monoclonal ARH / LDLRAP1 Antibody (clone 4G4-D5), Clone: 4G4-D5

APG01983G 0.05mg
EUR 528
Description: A Monoclonal antibody against Human ARH / LDLRAP1 (clone 4G4-D5). The antibodies are raised in Mouse and are from clone 4G4-D5. This antibody is applicable in WB and IHC-P, IF, E

Mouse D5 ELISA Kit

EMD0012 96Tests
EUR 521

Porcine D5 ELISA Kit

EPD0012 96Tests
EUR 521

Rat D5 ELISA Kit

ERD0012 96Tests
EUR 521

Rabbit D5 ELISA Kit

ERTD0012 96Tests
EUR 521

4-Hydroxyphenyl Carvedilol D5

HY-12767S 1mg
EUR 422

Enalaprilat D5 (Sodium Salt)

HY-B0231BS 10mg
EUR 2405

Anserini D5 ELISA Kit

EAD0012 96Tests
EUR 521

Goat D5 ELISA Kit

EGTD0012 96Tests
EUR 521

Canine D5 ELISA Kit

ECD0012 96Tests
EUR 521

Human D5 ELISA Kit

EHD0012 96Tests
EUR 521

Bovine D5 ELISA Kit

EBD0012 96Tests
EUR 521

Dopamine Receptor D5 Antibody

20-abx225151
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul

([ring-D5]Phe3)-Octreotide

H-7238.0500 0.5mg
EUR 793
Description: Sum Formula: C49H61D5N10O10S2; CAS# [1134880-79-7] net

([ring-D5]Phe3)-Octreotide

H-7238.1000 1.0mg
EUR 1205
Description: Sum Formula: C49H61D5N10O10S2; CAS# [1134880-79-7] net

Anti-ARH (4G4-D5)

YF-MA11424 100 ug
EUR 363
Description: Mouse monoclonal to ARH

Anti-LFA3 (3B12-D5)

YF-MA12346 100 ug
EUR 363
Description: Mouse monoclonal to LFA3

Vitamin C(Vitamin C)ELISA Kit

QY-E160029 96T
EUR 413

Vitamin B12

AT115 1mg
EUR 1368

Vitamin B2

AT206 1mg
EUR 1114

Vitamin CK3

HY-16516 100mg
EUR 119

Vitamin D4

HY-75958 1mg
EUR 271

Vitamin D2

HY-76542 10mM/1mL
EUR 113

Vitamin B12

HY-B0315 500mg
EUR 119

Vitamin K4

HY-B1508 1g
EUR 173

Vitamin K

HY-B2172 500mg
EUR 215

Vitamin K1

HY-N0684 500mg
EUR 108

Vitamin B12

AG115 1 mg
EUR 523

Vitamin B2

AG206 1 mg
EUR 523

Vitamin B12

abx082092-1g 1 g
EUR 217

Vitamin D3

20-abx185612
  • EUR 1497.00
  • EUR 328.00
  • 10 g
  • 1 g

Vitamin B2

abx188930-5g 5 g
EUR 203

Vitamin D2

20-abx184475
  • EUR 592.00
  • EUR 1247.00
  • EUR 384.00
  • 10 g
  • 25 g
  • 5 g

Vitamin B12

GE2859-1G 1 g
EUR 70

Vitamin B12

GE2859-10G 10 g
EUR 190

Vitamin B12

GE2859-25G 25 g
EUR 333

Vitamin B12

GE2859-5G 5 g
EUR 126

Vitamin B12

B2063-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Vitamin B12

Vitamin B12

B2063-50 50 mg
EUR 128
Description: Vitamin B12

Vitamin B12

B2063-S Evaluation Sample
EUR 81
Description: Vitamin B12

Vitamin C

B2064-5.1 10 mM (in 1mL DMSO)
EUR 108
Description: Ascorbic acid is a naturally occurring organic compound with antioxidant properties.

Vitamin C

B2064-50 50 mg
EUR 128
Description: Ascorbic acid is a naturally occurring organic compound with antioxidant properties.

Vitamin D3

B2065-5000 5 g
EUR 139
Description: Cholecalciferol is a naturally occuring form of vitamin D. Reported that upon metabolic activation, Cholecalciferol induces cell differentiation and prevents proliferation of cancer cells.

Vitamin E

B6145-100 100 mg
EUR 196

Vitamin E

B6145-500 500 mg
EUR 463

Vitamin K3

GV3614-25G 25 g
EUR 62

Vitamin K1

GV4612-1G 1 g
EUR 74

Vitamin D2

GV6132-1G 1 g
EUR 78

Vitamin D2

GV6132-5G 5 g
EUR 198

Vitamin K1

TBZ2488 100mg Ask for price

VitaMin K5

TBZ2840 500mg Ask for price

Vitamin A

B2456-250
EUR 262

Vitamin A

B2456-50
EUR 131

Vitamin E

TB02699 4X20mg
EUR 268

Vitamin B12

TBW00737 8XX20mg
EUR 274

Vitamin C

TBW00996 100mg Ask for price

Vitamin K2

TBW01027 20mg Ask for price

FLT1-D5 Vascular Endothelial Growth Factor Receptor-1 D5 Human Recombinant Protein

PROTP17948-2 Regular: 10ug
EUR 317
Description: Soluble FLT1 D1-5 Human Recombinant produced in baculovirus is monomeric, glycosylated, polypeptide containing 562 amino acids and having a molecular mass of 70 kDa. The soluble receptor protein contains only the first 5 extracellular domains, which contain all the information necessary for binding of VEGF.;The FLT1 is purified by proprietary chromatographic techniques.

Monoclonal CRYAB / Alpha B Crystallin Antibody (clone 1A7.D5), Clone: 1A7.D5

APG02802G 0.1mg
EUR 484
Description: A Monoclonal antibody against Human CRYAB / Alpha B Crystallin (clone 1A7.D5). The antibodies are raised in Mouse and are from clone 1A7.D5. This antibody is applicable in WB and IHC-P, E

Mouse Monoclonal Anti-Human CD3 FITC/CD8 PE

CD03-D5-50 50 tests
EUR 651

Transferrin antibody

20-D3913GN01-D5 10 ml
EUR 203
Description: Polyclonal Transferrin antibody

Anti-Dynamin Antibody (Monoclonal, D5)

M02536 100ug/vial
EUR 397
Description: Mouse Monoclonal Dynamin Antibody (Monoclonal, D5). Validated in IP, WB and tested in Human, Mouse, Rat.

O-Desmethyl Mebeverine acid D5

HY-12771S 5mg
EUR 1083

5-Hydroxy Propafenone (D5 Hydrochloride)

HY-12773AS 10mg
EUR 2460

Guinea Pig D5 ELISA Kit

EGD0012 96Tests
EUR 521

Dopamine Receptor D5 (DRD5) Antibody

20-abx112162
  • EUR 732.00
  • EUR 398.00
  • 150 ul
  • 50 ul

Inactive phospholipase D5 Antibody (Biotin)

20-abx105551
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Inactive phospholipase D5 Antibody (FITC)

20-abx106968
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Inactive phospholipase D5 Antibody (HRP)

20-abx108389
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Inactive Phospholipase D5 (PLD5) Antibody

20-abx109904
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Dopamine Receptor D5 (DRD5) Antibody

20-abx001436
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Inactive Phospholipase D5 (PLD5) Antibody

abx026346-400ul 400 ul
EUR 523

Inactive Phospholipase D5 (PLD5) Antibody

abx026346-80l 80 µl
EUR 286

CD56 / NCAM(123C3.D5) Antibody

BNCA0015-250 250uL
EUR 383
Description: Primary antibody against CD56 / NCAM(123C3.D5), APC conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCA0045-250 250uL
EUR 383
Description: Primary antibody against bcl-2(100/D5), APC conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNCAP0015-100 100uL
EUR 199
Description: Primary antibody against CD56 / NCAM(123C3.D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNCAP0015-500 500uL
EUR 544
Description: Primary antibody against CD56 / NCAM(123C3.D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCAP0045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCAP0045-500 500uL
EUR 544
Description: Primary antibody against bcl-2(100/D5), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNC810015-100 100uL
EUR 199
Description: Primary antibody against CD56 / NCAM(123C3.D5), CF680R conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNC810015-500 500uL
EUR 544
Description: Primary antibody against CD56 / NCAM(123C3.D5), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC810045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF680R conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC810045-500 500uL
EUR 544
Description: Primary antibody against bcl-2(100/D5), CF680R conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNC880015-100 100uL
EUR 199
Description: Primary antibody against CD56 / NCAM(123C3.D5), CF488A conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNC880015-500 500uL
EUR 544
Description: Primary antibody against CD56 / NCAM(123C3.D5), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC880045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), CF488A conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNC880045-500 500uL
EUR 544
Description: Primary antibody against bcl-2(100/D5), CF488A conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNCB0015-100 100uL
EUR 199
Description: Primary antibody against CD56 / NCAM(123C3.D5), Biotin conjugate, Concentration: 0.1mg/mL

CD56 / NCAM(123C3.D5) Antibody

BNCB0015-500 500uL
EUR 544
Description: Primary antibody against CD56 / NCAM(123C3.D5), Biotin conjugate, Concentration: 0.1mg/mL

bcl-2(100/D5) Antibody

BNCB0045-100 100uL
EUR 199
Description: Primary antibody against bcl-2(100/D5), Biotin conjugate, Concentration: 0.1mg/mL
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