Recent progress in the research of cold-inducible RNA-binding protein.

Recent progress in the research of cold-inducible RNA-binding protein.

Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein which will be induced after publicity to a reasonable cold-shock in totally different species starting from amphibians to people. Expression of CIRP may also be regulated by hypoxia, UV radiation, glucose deprivation, warmth stress and H2O2, suggesting that CIRP is a basic stress-response protein. In response to emphasize, CIRP can migrate from the nucleus to the cytoplasm and regulate mRNA stability by means of its binding website on the 3′-UTR of its focused mRNAs.

Through the regulation of its targets, CIRP has been implicated in a number of mobile course of similar to cell proliferation, cell survival, circadian modulation, telomere upkeep and tumor formation and development. In addition, CIRP can even exert its features by straight interacting with intracellular signaling proteins.

Moreover, CIRP will be secreted out of cells. Extracellular CIRP features as a damage-associated molecular sample to advertise inflammatory responses and performs an necessary function in each acute and power inflammatory ailments. Here, we summarize novel findings of CIRP investigation and hope to supply insights into the function of CIRP in cell biology and ailments.

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative illness with no efficient remedies. Numerous RNA-binding proteins (RBPs) have been proven to be altered in ALS, with mutations in 11 RBPs inflicting familial varieties of the illness, and 6 extra RBPs exhibiting irregular expression/distribution in ALS albeit with none identified mutations.

RBP dysregulation is extensively accepted as a contributing issue in ALS pathobiology. There are at the least 1542 RBPs in the human genome; due to this fact, different unidentified RBPs can also be linked to the pathogenesis of ALS. We used IBM Watson® to sieve by means of all RBPs in the genome and determine new RBPs linked to ALS (ALS-RBPs). IBM Watson extracted options from revealed literature to create semantic similarities and determine new connections between entities of curiosity.

IBM Watson analyzed all revealed abstracts of beforehand identified ALS-RBPs, and utilized that text-based information to all RBPs in the genome, rating them by semantic similarity to the identified set.

Recent progress in the research of cold-inducible RNA-binding protein.
Recent progress in the research of cold-inducible RNA-binding protein.

We then validated the Watson top-ten-ranked RBPs at the protein and RNA ranges in tissues from ALS and non-neurological illness controls, in addition to in patient-derived induced pluripotent stem cells. 5 RBPs beforehand unlinked to ALS, hnRNPU, Syncrip, RBMS3, Caprin-1 and NUPL2, confirmed vital alterations in ALS in comparison with controls. Overall, we efficiently used IBM Watson to assist determine extra RBPs altered in ALS, highlighting the use of synthetic intelligence instruments to speed up scientific discovery in ALS and presumably different complicated neurological issues.

CRF Anti-Polyvalent HRP Polymer (DAB) Stain Kit

CPH080 80 Slides
EUR 187.2

DAB

HY-15912 500mg
EUR 129.6

Fmoc-Dab[Fmoc-Dab(Boc)]-OH

5-04727 5g Ask for price

Fmoc-Dab[Fmoc-Dab(Boc)]-OH

5-04728 25g Ask for price

DAB Tablet

D3225-020 20TB
EUR 170.4

DAB Tablet

D3225-050 50TB
EUR 295.2

Giemsa stain

20-abx082069
  • EUR 210.00
  • EUR 260.40
  • 1 g
  • 5 g

Giemsa stain

20-abx082518
  • EUR 210.00
  • EUR 260.40
  • 1 g
  • 5 g

DiI Stain

B2742-250 250 mg
EUR 903.6

DiI Stain

B2742-50 50 mg
EUR 272.4

Giemsa stain

GB0477 10g
EUR 72.53

Jenner's Stain

GT5545-100G 100 g
EUR 192

Jenner's Stain

GT5545-25G 25 g
EUR 97.2

Giemsa Stain

GT6821-100ML 100 ml
EUR 55.2

Giemsa Stain

GT6821-250ML 250 ml
EUR 70.8

Wright's stain

GT7819-100G 100 g
EUR 132

Wright's stain

GT7819-10G 10 g
EUR 55.2

Wright's stain

GT7819-250G 250 g
EUR 228

Wright's stain

GT7819-25G 25 g
EUR 69.6

DAB Differentiating Solution

DDS500 500 ml
EUR 130.8

DAB Chromogen Concentrate

D3226-002 20ml
EUR 193.2

DAB Chromogen Concentrate

D3226-005 50ml
EUR 400.8

Z-Dab-OH

C-3705.0001 1.0g
EUR 138
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6]

Z-Dab-OH

C-3705.0005 5.0g
EUR 327.6
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6]

Z-Dab-OH

C-3705.0025 25.0g
EUR 1197.6
Description: Sum Formula: C12H16N2O4; CAS# [62234-40-6]

DAB Chromogen Concentrate

ACB030 30 ml
EUR 142.8

DAB Chromogen Concentrate

ACB060 60 ml
EUR 198

DAB Chromogen Concentrate

ACB125 125 ml
EUR 294

DAB Chromogen Concentrate

ACB500 500 ml
EUR 805.2

DAB Chromogen Concentrate

ACB999 1000 ml
EUR 1390.8

DAB Substrate Buffer

ACC500 500 ml
EUR 86.4

DAB Substrate Buffer

ACC999 1000 ml
EUR 96

DAB Enhancer Solution

ACM030 30 ml
EUR 85.2

DAB Away Kit

ACP001 500 ml
EUR 117.6

H-Dab-OH

F-3050.0001 1.0g
EUR 138
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6]

H-Dab-OH

F-3050.0005 5.0g
EUR 270
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6]

H-Dab-OH

F-3050.0025 25.0g
EUR 963.6
Description: Sum Formula: C4H10N2O2; CAS# [1883-09-6]

H-Dab-OH·HCl

5-04703 5g Ask for price

H-Dab-OH·HCl

5-04704 25g Ask for price

Boc-Dab-OH

5-04711 5g Ask for price

Boc-Dab-OH

5-04712 25g Ask for price

Fmoc-Dab-OAll·HCl

5-04720 5g Ask for price

Fmoc-Dab-OH·HCl

5-04721 5g Ask for price

Fmoc-Dab-OH·HCl

5-04722 25g Ask for price

Fmoc-Dab-OH

5-04735 1g Ask for price

Fmoc-Dab-OH

5-04736 5g Ask for price

DAB Substrate kit

30015 1Kit
EUR 171.6
Description: Minimum order quantity: 1 unit of 1Kit

DAB Chromogen Kit

abx097197-1Kit 1 Kit
EUR 326.4

DL-Dab.2HCl

A6727-100000 100 g
EUR 682.8
Description: DL-Dab.2HCl

DL-Dab.2HCl

A6727-25000 25 g
EUR 370.8
Description: DL-Dab.2HCl

DL-Dab.2HCl

A6727-5000 5 g
EUR 216
Description: DL-Dab.2HCl

Boc-Dab-OH

A-3215.0001 1.0g
EUR 151.2
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6]

Boc-Dab-OH

A-3215.0005 5.0g
EUR 501.6
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6]

Boc-Dab-OH

A-3215.0025 25.0g
EUR 1893.6
Description: Sum Formula: C9H18N2O4; CAS# [25691-37-6]

Fmoc-Dab-OH

B-2300.0001 1.0g
EUR 181.2
Description: Sum Formula: C19H20N2O4; CAS# [161420-87-7]

Fmoc-Dab-OH

B-2300.0005 5.0g
EUR 618
Description: Sum Formula: C19H20N2O4; CAS# [161420-87-7]

DAB Chromogen, 4ml

NB314D 4 ml
EUR 295.2

DAB Enhancer for ampliying DAB stains in IHC staining, 60ml

NB308 60 ml
EUR 512.4

DAB Enhancer for ampliying DAB stains in IHC staining, 30ml

NB308-30 30 ml
EUR 358.8

Protein Stain-EZ C, Reversible Copper Stain Kit

BSP017 1kit, 10prep
EUR 89.23

Protein Stain-EZ B, Reversible Zinc Stain Kit

BSP019 1kit, 10prep
EUR 89.23

Protein Stain-EZG Rapid Coomassie Blue Stain Solution

BSP041 1KIT, 10prep
EUR 91.32

10-DAB (10-Deacetylbaccatin)

A4395-25 25 mg
EUR 616.8
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

10-DAB (10-Deacetylbaccatin)

A4395-5 5 mg
EUR 199.2
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

10-DAB (10-Deacetylbaccatin)

A4395-5.1 10 mM (in 1mL DMSO)
EUR 351.6
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

10-DAB (10-Deacetylbaccatin)

A4395-S Evaluation Sample
EUR 97.2
Description: 10-DAB (also known as 10-Deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the Pacific yew tree Taxus brevifolia as well as other species of the genus Taxus.

DAB (Post) Enhancing Solution

DES500 500 ml
EUR 105.6

DAB (Post) Enhancing Solution

DES999 1000 ml
EUR 130.8

Z-Dab(Z)-OH

C-3690.0001 1.0g
EUR 240
Description: Sum Formula: C20H22N2O6; CAS# [55478-23-4]

Z-Dab(Z)-OH

C-3690.0005 5.0g
EUR 835.2
Description: Sum Formula: C20H22N2O6; CAS# [55478-23-4]

Z-D-Dab-OH

C-3770.0001 1.0g
EUR 270
Description: Sum Formula: C12H16N2O4; CAS# [70882-66-5]

Z-D-Dab-OH

C-3770.0005 5.0g
EUR 950.4
Description: Sum Formula: C12H16N2O4; CAS# [70882-66-5]

DAB Substrate (High Contrast)

ACU250 250 ml
EUR 102

DAB Substrate (High Contrast)

ACU500 500 ml
EUR 117.6

DAB Substrate (High Contrast)

ACU999 1000 ml
EUR 142.8

DAB Chromogen/Substrate Kit

ACH500 500 Slides
EUR 102

Ac-Dab(Boc)-OH

F-1020.0250 250.0mg
EUR 283.2
Description: Sum Formula: C11H20N2O5; CAS# [201351-32-8]

Ac-Dab(Boc)-OH

F-1020.1000 1.0g
EUR 792
Description: Sum Formula: C11H20N2O5; CAS# [201351-32-8]

H-D-Dab-OH

F-3055.0001 1.0g
EUR 270
Description: Sum Formula: C4H10N2O2; CAS# [26908-94-1] net

H-D-Dab-OH

F-3055.0005 5.0g
EUR 950.4
Description: Sum Formula: C4H10N2O2; CAS# [26908-94-1] net

H-Dab(Z)-OH

5-04707 5g Ask for price

H-Dab(Z)-OH

5-04708 25g Ask for price

Boc-Dab(Boc)-OH·DCHA

5-04713 1g Ask for price

Boc-Dab(Boc)-OH·DCHA

5-04714 5g Ask for price

Boc-Dab(Fmoc)-OH

5-04715 5g Ask for price

Boc-Dab(Fmoc)-OH

5-04716 25g Ask for price

Boc-Dab(Z)-OH·DCHA

5-04717 5g Ask for price

Boc-Dab(Z)-OH·DCHA

5-04718 25g Ask for price

Fmoc-Dab(Ac)-OH

5-04723 5g Ask for price

Fmoc-Dab(Ac)-OH

5-04724 25g Ask for price

Fmoc-Dab(Boc)-OH

5-04725 5g Ask for price

Fmoc-Dab(Boc)-OH

5-04726 25g Ask for price

Fmoc-Dab(Fmoc)-OH

5-04729 1g Ask for price

Fmoc-Dab(Fmoc)-OH

5-04730 5g Ask for price

Fmoc-Dab(MMt)-OH

5-04731 5g Ask for price

Fmoc-Dab(MMt)-OH

5-04732 25g Ask for price

Fmoc-Dab(Mtt)-OH

5-04733 1g Ask for price

Fmoc-Dab(Mtt)-OH

5-04734 5g Ask for price

Fmoc-Dab(Dde)-OH

5-04739 1g Ask for price

Fmoc-Dab(Dde)-OH

5-04740 5g Ask for price

Fmoc-Dab(ivDde)-OH

5-04741 1g Ask for price

Fmoc-Dab(ivDde)-OH

5-04742 5g Ask for price

Fmoc-Dab(Z)-OH

5-04743 1g Ask for price

Fmoc-Dab(Z)-OH

5-04744 5g Ask for price

Boc-D-Dab-OH

5-04745 1g Ask for price

Boc-D-Dab-OH

5-04746 5g Ask for price

Fmoc-D-Dab-OH

5-04751 1g Ask for price

Fmoc-D-Dab-OH

5-04752 5g Ask for price

Fmoc-Dab(Fmoc)-Oh

abx188721-250g 250 g
EUR 2064

H-Dab(Boc)-OH

A-3305.0001 1.0g
EUR 240
Description: Sum Formula: C9H18N2O4; CAS# [10270-94-7]

H-Dab(Boc)-OH

A-3305.0005 5.0g
EUR 835.2
Description: Sum Formula: C9H18N2O4; CAS# [10270-94-7]

Boc-Dab(Fmoc)-OH

A-3520.0001 1.0g
EUR 270
Description: Sum Formula: C24H28N2O6; CAS# [117106-21-5]

Boc-Dab(Fmoc)-OH

A-3520.0005 5.0g
EUR 936
Description: Sum Formula: C24H28N2O6; CAS# [117106-21-5]

Boc-Dab(Aloc)-OH

A-4125.0001 1.0g
EUR 370.8
Description: Sum Formula: C13H22N2O6; CAS# [171820-73-8]

Boc-Dab(Aloc)-OH

A-4125.0005 5.0g
EUR 1371.6
Description: Sum Formula: C13H22N2O6; CAS# [171820-73-8]

Boc-D-Dab-OH

A-4215.0001 1.0g
EUR 501.6
Description: Sum Formula: C9H18N2O4; CAS# [80445-78-9]

Boc-D-Dab-OH

A-4215.0005 5.0g
EUR 1864.8
Description: Sum Formula: C9H18N2O4; CAS# [80445-78-9]

Boc-Dab-OtBu · HCl

A-4415.0001 1.0g
EUR 370.8
Description: Sum Formula: C13H26N2O4·HCl; CAS# [190447-69-9] net

Boc-Dab-OtBu · HCl

A-4415.0005 5.0g
EUR 1371.6
Description: Sum Formula: C13H26N2O4·HCl; CAS# [190447-69-9] net

Fmoc-Dab(ivDde)-OH

B-4065.0001 1.0g
EUR 356.4
Description: Sum Formula: C32H38N2O6; CAS# [607366-21-2]

Fmoc-Dab(ivDde)-OH

B-4065.0005 5.0g
EUR 1311.6
Description: Sum Formula: C32H38N2O6; CAS# [607366-21-2]

Fmoc-Dab(Boc)-OH

B-1800.0001 1.0g
EUR 240
Description: Sum Formula: C24H28N2O6; CAS# [125238-99-5]

Fmoc-Dab(Boc)-OH

B-1800.0005 5.0g
EUR 819.6
Description: Sum Formula: C24H28N2O6; CAS# [125238-99-5]

Fmoc-Dab(Fmoc)-OH

B-2270.0001 1.0g
EUR 283.2
Description: Sum Formula: C34H30N2O6; CAS# [201473-83-8]

Fmoc-Dab(Fmoc)-OH

B-2270.0005 5.0g
EUR 1039.2
Description: Sum Formula: C34H30N2O6; CAS# [201473-83-8]

Fmoc-D-Dab-OH

B-2365.0001 1.0g
EUR 501.6
Description: Sum Formula: C19H20N2O4; CAS# [201484-12-0]

Fmoc-D-Dab-OH

B-2365.0005 5.0g
EUR 1864.8
Description: Sum Formula: C19H20N2O4; CAS# [201484-12-0]

Fmoc-Dab(Aloc)-OH

B-2850.0001 1.0g
EUR 356.4
Description: Sum Formula: C23H24N2O6; CAS# [204316-32-5]

Fmoc-Dab(Aloc)-OH

B-2850.0005 5.0g
EUR 1327.2
Description: Sum Formula: C23H24N2O6; CAS# [204316-32-5]

Fmoc-Dab(Z)-OH

B-3250.0001 1.0g
EUR 313.2
Description: Sum Formula: C27H26N2O6; CAS# [252049-08-4]

Fmoc-Dab(Z)-OH

B-3250.0005 5.0g
EUR 1110
Description: Sum Formula: C27H26N2O6; CAS# [252049-08-4]

DAB Substrate buffer, 70ml

NB314SB 70 ml
EUR 331.2

Copper Stain Kit

CSK-1 1 kit(s)
EUR 226.8

Fite's Stain Kit

FLS-1 125 ml ea.
EUR 178.8

Fite's Stain Kit

FLS-500 500 ml ea.
EUR 354

ClearSight DNA Stain

BH40501 1ml
EUR 123.6
Description: For DNA staining and vizualization.

ClearSight RNA Stain

BH40601 400µl
EUR 92.4
Description: For DNA staining and vizualization.

Silver Stain kit

AR0171 1 kit (for 30 assays to stain the gel of 5 X8.5)
EUR 182.4

GMS Stain Kit

KAA-1 125 ml ea.
EUR 259.2

GMS Stain Kit

KAA-1000 1000 ml ea.
EUR 1060.8

GMS Stain Kit

KAA-500 500 ml ea.
EUR 627.6

Iron Stain Kit

IRN-1 1 kit(s)
EUR 178.8

Iron Stain Kit

IRN-2 100 Slides
EUR 121.2

Fite's Stain Kit

K1425-125
EUR 444

Geimsa Stain Kit

K1426-30
EUR 346.8

Geimsa Stain Kit

K1426-500
EUR 561.6

GMS Stain Kit

K1427-125
EUR 535.2

Gram Stain Kit

k1428-125
EUR 470.4

Gram Stain Kit

k1428-30
EUR 314.4

Orcein Stain Kit

K1432-125
EUR 601.2

Orcein Stain Kit

K1432-30
EUR 430.8

Pneumocystis Stain Kit

K1434-125
EUR 510

Pneumocystis Stain Kit

K1434-30
EUR 379.2

Steiner Stain Kit

K1435-125
EUR 535.2

Papanicolaou Stain Kit

K1440-30
EUR 248.4

Papanicolaou Stain Kit

K1440-500
EUR 333.6

Reticulum Stain Kit

GRT-1 1 kit(s)
EUR 306

Reticulum Stain Kit

GRT-2 1 kit(s)
EUR 182.4

Gram Stain Kit

GSK-1 125 ml ea.
EUR 150

Gram Stain Kit

GSK-2 30 ml ea.
EUR 110.4

Gram Stain Kit

GSK-500 500 ml ea.
EUR 363.6

Jenner's Stain, certified

GT1148-25G 25 g
EUR 128.4

Giemsa stain, powder

GT7801-100G 100 g
EUR 160.8

Giemsa stain, powder

GT7801-10G 10 g
EUR 55.2

Giemsa stain, powder

GT7801-25G 25 g
EUR 74.4

Giemsa stain, powder

GT7801-50G 50 g
EUR 103.2

Giemsa stain, powder

GT7801-5G 5 g
EUR 50.4

Pneumocystis Stain Kit

PCS-1 1 kit(s)
EUR 187.2

Pneumocystis Stain Kit

PCS-2 100 Slides
EUR 124.8

4CN Stain Kit

PW024 5Preps, 5prep
EUR 85.06

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