Recent progress in the research of cold-inducible RNA-binding protein.

Recent progress in the research of cold-inducible RNA-binding protein.

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Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein which will be induced after publicity to a reasonable cold-shock in totally different species starting from amphibians to people. Expression of CIRP may also be regulated by hypoxia, UV radiation, glucose deprivation, warmth stress and H2O2, suggesting that CIRP is a basic stress-response protein. In response to emphasize, CIRP can migrate from the nucleus to the cytoplasm and regulate mRNA stability by means of its binding website on the 3′-UTR of its focused mRNAs.

Through the regulation of its targets, CIRP has been implicated in a number of mobile course of similar to cell proliferation, cell survival, circadian modulation, telomere upkeep and tumor formation and development. In addition, CIRP can even exert its features by straight interacting with intracellular signaling proteins.

Moreover, CIRP will be secreted out of cells. Extracellular CIRP features as a damage-associated molecular sample to advertise inflammatory responses and performs an necessary function in each acute and power inflammatory ailments. Here, we summarize novel findings of CIRP investigation and hope to supply insights into the function of CIRP in cell biology and ailments.

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative illness with no efficient remedies. Numerous RNA-binding proteins (RBPs) have been proven to be altered in ALS, with mutations in 11 RBPs inflicting familial varieties of the illness, and 6 extra RBPs exhibiting irregular expression/distribution in ALS albeit with none identified mutations.

RBP dysregulation is extensively accepted as a contributing issue in ALS pathobiology. There are at the least 1542 RBPs in the human genome; due to this fact, different unidentified RBPs can also be linked to the pathogenesis of ALS. We used IBM Watson® to sieve by means of all RBPs in the genome and determine new RBPs linked to ALS (ALS-RBPs). IBM Watson extracted options from revealed literature to create semantic similarities and determine new connections between entities of curiosity.

IBM Watson analyzed all revealed abstracts of beforehand identified ALS-RBPs, and utilized that text-based information to all RBPs in the genome, rating them by semantic similarity to the identified set.

Recent progress in the research of cold-inducible RNA-binding protein.
Recent progress in the research of cold-inducible RNA-binding protein.

We then validated the Watson top-ten-ranked RBPs at the protein and RNA ranges in tissues from ALS and non-neurological illness controls, in addition to in patient-derived induced pluripotent stem cells. 5 RBPs beforehand unlinked to ALS, hnRNPU, Syncrip, RBMS3, Caprin-1 and NUPL2, confirmed vital alterations in ALS in comparison with controls. Overall, we efficiently used IBM Watson to assist determine extra RBPs altered in ALS, highlighting the use of synthetic intelligence instruments to speed up scientific discovery in ALS and presumably different complicated neurological issues.

DAB Buffer, 10X For use with DAB Staining System for HRPO
MBS639268-100mL 100mL
EUR 320

DAB Buffer, 10X For use with DAB Staining System for HRPO
MBS639268-250mL 250mL
EUR 395

DAB Buffer, 10X For use with DAB Staining System for HRPO
MBS639268-500mL 500mL
EUR 500

DAB Buffer, 10X For use with DAB Staining System for HRPO
MBS639268-50mL 50mL
EUR 280

DAB Buffer, 10X For use with DAB Staining System for HRPO
MBS639268-5x500mL 5x500mL
EUR 2090

DAB Enhancer for ampliying and darkening DAB stains in IHC staining, 60 ml (Large volume)
NB308 60 ml
EUR 435

DAB Enhancer for ampliying and darkening DAB stains in IHC staining, 30 ml (Small volume)
NB308-30 30 ml
EUR 285

Neat Stain Gram Stain Kit
25036-1 1Kit
EUR 130.68

Mouse to Mouse HRP (DAB) Staining System
MTM001 70 Slides
EUR 86.15

Neat Stain Hematology Stain Kit
25034-4 1kit
EUR 96.12

SensiTek HRP Anti-Mouse (DAB) Staining System
AEA080 70 Slides
EUR 55.28

UltraTek HRP Anti-Mouse (DAB) Staining System
AKA080 70 Slides
EUR 61.72

SensiTek HRP Anti-Rabbit (DAB) Staining System
AEI080 70 Slides
EUR 55.28

UltraTek HRP Anti-Rabbit (DAB) Staining System
AKC080 70 Slides
EUR 61.72

UltraTek HRP Anti-Polyvalent (DAB) Staining System
AMF080 70 Slides
EUR 70.71

SensiTek HRP Anti-Polyvalent (DAB) Staining System
AEM080 70 Slides
EUR 61.72

ACQUA STAIN One-Step Protein Stain
AS001000 1 L
EUR 68

Gel Stain
abx098146-100l 100 µl
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Gel Stain
abx098146-200l 200 µl
EUR 400

DiI Stain
B2742-250 250 mg
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DiI Stain
B2742-50 50 mg
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Bowie's Stain
B17757 1G
EUR 176.42
Description: CAS N° 000-00-0

Giemsa Stain
45881 25 Gms
EUR 4.11
Description: Part A

Giemsa Stain
21770019-1 5 g
EUR 41.54

Giemsa Stain
21770019-2 25 g
EUR 141.19

Wright Stain
21770034-1 25 g
EUR 60.02

Wright Stain
21770034-2 100 g
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Wright Stain
13111 25 Gms
EUR 4.5
Description: Part B

Giemsa stain
20-abx082518
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Giemsa stain
abx082069-100l 100 µl
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Giemsa stain
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Giemsa stain
abx082069-200l 200 µl
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Giemsa Stain
G01600 25G
EUR 197.96
Description: CAS N° 51811-82-6

Giemsa stain
GB0477 10g
EUR 72.53

Giemsa Stain
GT6821 100ml
EUR 26.6

Giemsa Stain
GT6821-100 100
EUR 17.2

Giemsa Stain
GT6821-100ML 100 ml
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Giemsa Stain
GT6821-250 250
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Giemsa Stain
GT6821-250ML 250 ml
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Wright's stain
GT7819 10g
EUR 144.84

Wright's stain
GT7819-10 10
EUR 15.9

Wright's stain
GT7819-100 100
EUR 79.1

Wright's stain
GT7819-100G 100 g
EUR 132

Wright's stain
GT7819-10G 10 g
EUR 55.2

Wright's stain
GT7819-25 25
EUR 27.8

Wright's stain
GT7819-250 250
EUR 158.2

Wright's stain
GT7819-250G 250 g
EUR 228

Wright's stain
GT7819-25G 25 g
EUR 69.6

Jenner's Stain
GT5545 25g
EUR 117.98

Jenner's Stain
GT5545-100 100
EUR 128.9

Jenner's Stain
GT5545-100G 100 g
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Jenner's Stain
GT5545-25 25
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Jenner's Stain
GT5545-25G 25 g
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Giemsa’s Stain
S011-100ML 1 unit
EUR 6
Description: Giemsa’s Stain

Giemsa’s Stain
S011-500ML 1 unit
EUR 26.37
Description: Giemsa’s Stain

Giemsa stain
T60606-10mg 10mg Ask for price
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Giemsa stain
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Giemsa stain
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Giemsa stain
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Description: Giemsa stain

Jenners Stain
J00140 5G
EUR 121.13
Description: CAS N° 62851-42-7

Wrights Stain
S030-500ML 1 unit
EUR 8.52
Description: Wrights Stain

Elastin stain
RM9531-5G 1 unit
EUR 170.98
Description: Elastin stain

Protein Stain-EZ B, Reversible Zinc Stain Kit
BSP019 1kit, 10prep
EUR 89.23

Leishman Stain
82184 25 Gms
EUR 4.52
Description: Part A

Leishman Stain
RRSP78-D 500ml
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Leishman Stain
RRSP78-E 1L
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Leishman Stain
RRSP78-F 2.5L
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Protein Stain-EZ C, Reversible Copper Stain Kit
BSP017 1kit, 10prep
EUR 89.23

Leishmans Stain
L02470 25G
EUR 91.2
Description: CAS N° 12627-53-1

Papanicolaou Stain
O03035 500ML
EUR 247.2
Description: CAS N° 64-17-5

Protein Stain-EZG Rapid Coomassie Blue Stain Solution
BSP041 1KIT, 10prep
EUR 91.32

GMS Stain Kit
KAA-1 125 ml ea.
EUR 133.71

GMS Stain Kit
KAA-1000 1000 ml ea.
EUR 669.71

GMS Stain Kit
KAA-500 500 ml ea.
EUR 380.17

GMS Stain Kit
K1427-125 each
EUR 535.2

4CN Stain Kit
PW024 5Preps, 5prep
EUR 85.06

TMB Stain Kit
PW025 5Preps, 5prep
EUR 85.06

SYPRO Red Stain 500ul
LO50543 each
EUR 365.92

No-Dye Stain
40140070-1 25 mL
EUR 69.53

No-Dye Stain
40140070-2 100 mL
EUR 161.43

Rubeo™ Stain
21470010-1 200 mL
EUR 82.74

Rubeo™ Stain
21470010-2 500 mL
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Eosin Y Stain
21770035-1 500 mL
EUR 37.8

Eosin Y Stain
21770035-2 1 L
EUR 62.03

Gel Stain Blue
abx298033-100g 100 µg
EUR 1062.5

Gel Stain Blue
abx298033-20g 20 µg
EUR 312.5

Gel Stain Blue
abx298033-50g 50 µg
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Iron Stain Kit
IRN-1 1 kit(s)
EUR 79.73

Iron Stain Kit
IRN-125 125 ml
EUR 84

Iron Stain Kit
IRN-2 100 Slides
EUR 41.14

Gram Stain Kit
GSK-1 125 ml ea.
EUR 60.43

Gram Stain Kit
GSK-2 30 ml ea.
EUR 33.42

Gram Stain Kit
GSK-500 500 ml ea.
EUR 203.14

Fite's Stain Kit
K1425-125 each
EUR 444

Gram Stain Kit
k1428-125 each
EUR 470.4

Gram Stain Kit
k1428-30 each
EUR 314.4

Fite's Stain Kit
FLS-1 125 ml ea.
EUR 79.73

Fite's Stain Kit
FLS-500 500 ml ea.
EUR 196.72

SYBR DNA Stain
PCR-273 5 x 1,8ml
EUR 36.44

Field’s Stain A
S008-125ML 1 unit
EUR 4.08
Description: Field’s Stain A

Field’s Stain A
S008-250ML 1 unit
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Description: Field’s Stain A

Field’s Stain A
S008-500ML 1 unit
EUR 14.39
Description: Field’s Stain A

Field’s Stain B
S009-125ML 1 unit
EUR 3.79
Description: Field’s Stain B

Field’s Stain B
S009-250ML 1 unit
EUR 4.74
Description: Field’s Stain B

Field’s Stain B
S009-500ML 1 unit
EUR 13.26
Description: Field’s Stain B

Van Gieson Stain - 500ML
VANG5H 500ML
EUR 536.11

Fields Stain A
F01383 25G
EUR 260.48
Description: CAS N° 000-00-0

Fields Stain B
F01385 25G
EUR 260.48
Description: CAS N° 17372-87-1

Hi-Zinc Stain
ML057-125ML 1 unit
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Description: Hi-Zinc Stain

Hi-Zinc Stain
ML057-250ML 1 unit
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Description: Hi-Zinc Stain

Albert’s Stain A
S001-125ML 1 unit
EUR 3.79
Description: Albert’s Stain A

Albert’s Stain A
S001-500ML 1 unit
EUR 13.26
Description: Albert’s Stain A

Albert’s Stain B
S002-125ML 1 unit
EUR 3.79
Description: Albert’s Stain B

Albert’s Stain B
S002-500ML 1 unit
EUR 13.26
Description: Albert’s Stain B

Copper Stain Kit
CSK-1 1 kit(s)
EUR 111.86

Silver Stain kit
AR0171 1 kit (for 30 assays to stain the gel of 5 X8.5)
EUR 182.4

Geimsa Stain Kit
K1426-30 each
EUR 346.8

Geimsa Stain Kit
K1426-500 each
EUR 561.6

Orcein Stain Kit
K1432-125 each
EUR 601.2

Orcein Stain Kit
K1432-30 each
EUR 430.8

Leishman''s stain
GT6256 25g
EUR 137.69

Leishman''s stain
GT6256-100 100
EUR 150.4

Leishman''s stain
GT6256-25 25
EUR 55.4

Steiner Stain Kit
K1435-125 each
EUR 535.2

Ponceau-S Stain
ML045-250ML 1 unit
EUR 15.11
Description: Ponceau-S Stain

Neissers Stain A
RRSP104-D 500ml
EUR 7.54

Neissers Stain A
RRSP104-E 1L
EUR 12.1

Neissers Stain A
RRSP104-F 2.5L
EUR 21.65

Neissers Stain B
RRSP105-D 500ml
EUR 7.54

Neissers Stain B
RRSP105-E 1L
EUR 12.1

Neissers Stain B
RRSP105-F 2.5L
EUR 21.65

Neissers Stain C
RRSP106-D 500ml
EUR 7.54

Neissers Stain C
RRSP106-E 1L
EUR 12.1

Neissers Stain C
RRSP106-F 2.5L
EUR 21.65

Neissers Stain D
RRSP107-D 500ml
EUR 7.54

Neissers Stain D
RRSP107-E 1L
EUR 12.1

Neissers Stain D
RRSP107-F 2.5L
EUR 21.65

Giemsa Stain RR88
RRSP54-3E-B 3L Dispenser
EUR 35.96

Giemsa Stain RR88
RRSP54-5E-B 5L Dispenser
EUR 46.58

Giemsa Stain RR88
RRSP54-D 500ml
EUR 7.92

Giemsa Stain RR88
RRSP54-E 1L
EUR 13.39

Giemsa Stain RR88
RRSP54-F 2.5L
EUR 26.06

Giemsa Stain RR88
RRSP54-G 5L
EUR 43.99

Giemsa Stain PR80
RRSP55-3E-B 3L Dispenser
EUR 29.54

Giemsa Stain PR80
RRSP55-5E-G 5L Dispenser
EUR 31.24

Giemsa Stain PR80
RRSP55-D 500ml
EUR 9.06

Giemsa Stain PR80
RRSP55-E 1L
EUR 12.49

Giemsa Stain PR80
RRSP55-F 2.5L
EUR 22.73

Giemsa Stain PR80
RRSP55-G 5L
EUR 29.54

GlycoGel Stain Kit
24693-1 1kit
EUR 830.52

Grams iodine stain
G05090 5G
EUR 186
Description: CAS N° 12298-68-9

Herovici's Stain Kit
HSK-1 1 kit(s)
EUR 76.22

May Grunwald Stain
RRSP87-3E-B 3L Dispenser
EUR 22.3

May Grunwald Stain
RRSP87-D 500ml
EUR 7.92

May Grunwald Stain
RRSP87-E 1L
EUR 11.32

May Grunwald Stain
RRSP87-F 2.5L
EUR 20.6

May Grunwald Stain
RRSP87-G 5L
EUR 22.3

May Grunwald Stain
RRSP87-G-B 5L Dispenser
EUR 28.25

Gel RedSafe Stain 10000X in water (Nucleic acid stain for Agarose Gels)
S445 0,5 ml
EUR 86

Gel GreenSafe Stain 10000X in water (Nucleic acid stain for Agarose Gels)
S440 0,5 ml
EUR 86

Reticulin Stain Kit
25094-250 250ml
EUR 938.52

Reticulin Stain Kit
25094-500 500ml
EUR 1173.96

Turk's Stain Solution
37212-45 500ML
EUR 17.5

Turk's Stain Solution
37212-74 100ML
EUR 12.25

Giemsa stain, powder
GT7801 5g
EUR 94

Giemsa stain, powder
GT7801-10 10
EUR 15.9

Giemsa stain, powder
GT7801-100 100
EUR 102.7

Giemsa stain, powder
GT7801-100G 100 g
EUR 160.8

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