Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein which will be induced after publicity to a reasonable cold-shock in totally different species starting from amphibians to people. Expression of CIRP may also be regulated by hypoxia, UV radiation, glucose deprivation, warmth stress and H2O2, suggesting that CIRP is a basic stress-response protein. In response to emphasize, CIRP can migrate from the nucleus to the cytoplasm and regulate mRNA stability by means of its binding website on the 3′-UTR of its focused mRNAs.
Through the regulation of its targets, CIRP has been implicated in a number of mobile course of similar to cell proliferation, cell survival, circadian modulation, telomere upkeep and tumor formation and development. In addition, CIRP can even exert its features by straight interacting with intracellular signaling proteins.
Moreover, CIRP will be secreted out of cells. Extracellular CIRP features as a damage-associated molecular sample to advertise inflammatory responses and performs an necessary function in each acute and power inflammatory ailments. Here, we summarize novel findings of CIRP investigation and hope to supply insights into the function of CIRP in cell biology and ailments.
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative illness with no efficient remedies. Numerous RNA-binding proteins (RBPs) have been proven to be altered in ALS, with mutations in 11 RBPs inflicting familial varieties of the illness, and 6 extra RBPs exhibiting irregular expression/distribution in ALS albeit with none identified mutations.
RBP dysregulation is extensively accepted as a contributing issue in ALS pathobiology. There are at the least 1542 RBPs in the human genome; due to this fact, different unidentified RBPs can also be linked to the pathogenesis of ALS. We used IBM Watson® to sieve by means of all RBPs in the genome and determine new RBPs linked to ALS (ALS-RBPs). IBM Watson extracted options from revealed literature to create semantic similarities and determine new connections between entities of curiosity.
IBM Watson analyzed all revealed abstracts of beforehand identified ALS-RBPs, and utilized that text-based information to all RBPs in the genome, rating them by semantic similarity to the identified set.
We then validated the Watson top-ten-ranked RBPs at the protein and RNA ranges in tissues from ALS and non-neurological illness controls, in addition to in patient-derived induced pluripotent stem cells. 5 RBPs beforehand unlinked to ALS, hnRNPU, Syncrip, RBMS3, Caprin-1 and NUPL2, confirmed vital alterations in ALS in comparison with controls. Overall, we efficiently used IBM Watson to assist determine extra RBPs altered in ALS, highlighting the use of synthetic intelligence instruments to speed up scientific discovery in ALS and presumably different complicated neurological issues.
DAB Enhancer for ampliying and darkening DAB stain |
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| NB308-30 | Innovex | 30 ml | EUR 245 |
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Description: DAB Enhancer for ampliying and darkening DAB stains in IHC staining, 30 ml (Small volume) |
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CRF Anti-Polyvalent HRP Polymer (DAB) Stain Kit |
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| CPH080 | ScyTek Laboratories | 80 Slides | EUR 84.85 |
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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| MBS639268-100mL | MyBiosource | 100mL | EUR 320 |
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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| MBS639268-250mL | MyBiosource | 250mL | EUR 395 |
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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| MBS639268-500mL | MyBiosource | 500mL | EUR 500 |
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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| MBS639268-50mL | MyBiosource | 50mL | EUR 280 |
DAB Buffer, 10X For use with DAB Staining System for HRPO |
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| MBS639268-5x500mL | MyBiosource | 5x500mL | EUR 2090 |
Mouse to Mouse HRP (DAB) Staining System |
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| MTM001 | ScyTek Laboratories | 70 Slides | EUR 86.15 |
Neat Stain Gram Stain Kit |
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| 25036-1 | Polysciences Europe GmbH | 1Kit | EUR 117 |
Neat Stain Hematology Stain Kit |
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| 25034-4 | Polysciences Europe GmbH | 1kit | EUR 85 |
SensiTek HRP Anti-Mouse (DAB) Staining System |
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| AEA080 | ScyTek Laboratories | 70 Slides | EUR 55.28 |
UltraTek HRP Anti-Mouse (DAB) Staining System |
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| AKA080 | ScyTek Laboratories | 70 Slides | EUR 61.72 |
SensiTek HRP Anti-Rabbit (DAB) Staining System |
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| AEI080 | ScyTek Laboratories | 70 Slides | EUR 55.28 |
UltraTek HRP Anti-Rabbit (DAB) Staining System |
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| AKC080 | ScyTek Laboratories | 70 Slides | EUR 61.72 |
UltraTek HRP Anti-Polyvalent (DAB) Staining System |
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| AMF080 | ScyTek Laboratories | 70 Slides | EUR 70.71 |
SensiTek HRP Anti-Polyvalent (DAB) Staining System |
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| AEM080 | ScyTek Laboratories | 70 Slides | EUR 61.72 |
DiI Stain |
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| B2742-250 | Biovision | 250 mg | EUR 903.6 |
DiI Stain |
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| B2742-50 | Biovision | 50 mg | EUR 272.4 |
Gel Stain |
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| abx098146-100l | Abbexa | 100 µl | EUR 312.5 |
Gel Stain |
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| abx098146-200l | Abbexa | 200 µl | EUR 400 |
Bowie's Stain |
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| B17757 | Pfaltz & Bauer | 1G | EUR 205.14 |
Giemsa stain |
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| 20-abx082069 | Abbexa |
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Giemsa stain |
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| 20-abx082518 | Abbexa |
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Giemsa Stain |
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| 21770019-1 | Glycomatrix | 5 g | EUR 32.27 |
Giemsa Stain |
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| 21770019-2 | Glycomatrix | 25 g | EUR 109.64 |
Wright Stain |
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| 21770034-1 | Glycomatrix | 25 g | EUR 46.61 |
Wright Stain |
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| 21770034-2 | Glycomatrix | 100 g | EUR 165.71 |
Giemsa’s Stain |
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| S011-100ML | EWC Diagnostics | 1 unit | EUR 6 |
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Description: Giemsa’s Stain |
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Giemsa’s Stain |
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| S011-500ML | EWC Diagnostics | 1 unit | EUR 26.37 |
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Description: Giemsa’s Stain |
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Wright Stain |
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| 13111 | Sisco Laboratories | 25 Gms | EUR 4.5 |
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Description: Part B |
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Giemsa Stain |
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| 45881 | Sisco Laboratories | 25 Gms | EUR 4.11 |
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Description: Part A |
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Jenner's Stain |
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| GT5545 | Glentham Life Sciences | 25g | EUR 117.98 |
Giemsa Stain |
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| GT6821 | Glentham Life Sciences | 100ml | EUR 26.6 |
Wright's stain |
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| GT7819 | Glentham Life Sciences | 10g | EUR 144.84 |
Giemsa Stain |
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| G01600 | Pfaltz & Bauer | 25G | EUR 230.18 |
Jenner's Stain |
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| GT5545-100 | Glentham Life Sciences | 100 | EUR 128.9 |
Jenner's Stain |
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| GT5545-100G | Glentham Life Sciences | 100 g | EUR 192 |
Jenner's Stain |
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| GT5545-25 | Glentham Life Sciences | 25 | EUR 50.6 |
Jenner's Stain |
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| GT5545-25G | Glentham Life Sciences | 25 g | EUR 97.2 |
Giemsa Stain |
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| GT6821-100 | Glentham Life Sciences | 100 | EUR 17.2 |
Giemsa Stain |
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| GT6821-100ML | Glentham Life Sciences | 100 ml | EUR 55.2 |
Giemsa Stain |
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| GT6821-250 | Glentham Life Sciences | 250 | EUR 29.1 |
Giemsa Stain |
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| GT6821-250ML | Glentham Life Sciences | 250 ml | EUR 70.8 |
Wright's stain |
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| GT7819-10 | Glentham Life Sciences | 10 | EUR 15.9 |
Wright's stain |
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| GT7819-100 | Glentham Life Sciences | 100 | EUR 79.1 |
Wright's stain |
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| GT7819-100G | Glentham Life Sciences | 100 g | EUR 132 |
Wright's stain |
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| GT7819-10G | Glentham Life Sciences | 10 g | EUR 55.2 |
Wright's stain |
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| GT7819-25 | Glentham Life Sciences | 25 | EUR 27.8 |
Wright's stain |
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| GT7819-250 | Glentham Life Sciences | 250 | EUR 158.2 |
Wright's stain |
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| GT7819-250G | Glentham Life Sciences | 250 g | EUR 228 |
Wright's stain |
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| GT7819-25G | Glentham Life Sciences | 25 g | EUR 69.6 |
Giemsa stain |
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| GB0477 | Bio Basic | 10g | EUR 72.53 |
Giemsa stain |
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| T60606-10mg | TargetMol Chemicals | 10mg | Ask for price |
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Description: Giemsa stain |
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Giemsa stain |
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| T60606-1g | TargetMol Chemicals | 1g | Ask for price |
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Description: Giemsa stain |
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Giemsa stain |
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| T60606-1mg | TargetMol Chemicals | 1mg | Ask for price |
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Description: Giemsa stain |
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Giemsa stain |
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| T60606-50mg | TargetMol Chemicals | 50mg | Ask for price |
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Description: Giemsa stain |
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Giemsa stain |
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| T60606-5mg | TargetMol Chemicals | 5mg | Ask for price |
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Description: Giemsa stain |
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Giemsa stain |
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| abx082069-100l | Abbexa | 100 µl | EUR 125 |
Giemsa stain |
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| abx082069-1ml | Abbexa | 1 ml | Ask for price |
Giemsa stain |
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| abx082069-200l | Abbexa | 200 µl | EUR 187.5 |
Elastin stain |
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| RM9531-5G | EWC Diagnostics | 1 unit | EUR 170.98 |
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Description: Elastin stain |
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Wrights Stain |
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| S030-500ML | EWC Diagnostics | 1 unit | EUR 8.52 |
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Description: Wrights Stain |
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Jenners Stain |
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| J00140 | Pfaltz & Bauer | 5G | EUR 140.85 |
Protein Stain-EZ B, Reversible Zinc Stain Kit |
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| BSP019 | Bio Basic | 1kit, 10prep | EUR 89.23 |
Leishman Stain |
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| 82184 | Sisco Laboratories | 25 Gms | EUR 4.52 |
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Description: Part A |
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Leishman Stain |
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| RRSP78-D | Atom Scientific | 500ml | EUR 7.92 |
Leishman Stain |
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| RRSP78-E | Atom Scientific | 1L | EUR 12.49 |
Leishman Stain |
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| RRSP78-F | Atom Scientific | 2.5L | EUR 19.31 |
Protein Stain-EZ C, Reversible Copper Stain Kit |
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| BSP017 | Bio Basic | 1kit, 10prep | EUR 89.23 |
Leishmans Stain |
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| L02470 | Pfaltz & Bauer | 25G | EUR 106.05 |
Protein Stain-EZG Rapid Coomassie Blue Stain Solution |
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| BSP041 | Bio Basic | 1KIT, 10prep | EUR 91.32 |
Papanicolaou Stain |
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| O03035 | Pfaltz & Bauer | 500ML | EUR 287.5 |
STAT-Q Multivalent DAB KIT for staining Mouse, Rat |
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| NB314KLD | Innovex | 1000 slides | EUR 895 |
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Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 1000 plus slides (Large size kit) |
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STAT-Q Multivalent DAB KIT for staining Mouse, Rat |
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| NB314KLD-20 | Innovex | 300 slide kit | EUR 595 |
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Description: STAT-Q Multivalent DAB KIT for staining Mouse, Rat and Rabbit antibodies, 350 slides kit (Small size Kit) |
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GMS Stain Kit |
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| KAA-1 | ScyTek Laboratories | 125 ml ea. | EUR 133.71 |
GMS Stain Kit |
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| KAA-1000 | ScyTek Laboratories | 1000 ml ea. | EUR 669.71 |
GMS Stain Kit |
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| KAA-500 | ScyTek Laboratories | 500 ml ea. | EUR 380.17 |
GMS Stain Kit |
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| K1427-125 | Biovision | each | EUR 535.2 |
4CN Stain Kit |
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| PW024 | Bio Basic | 5Preps, 5prep | EUR 85.06 |
TMB Stain Kit |
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| PW025 | Bio Basic | 5Preps, 5prep | EUR 85.06 |
SYPRO Red Stain 500ul |
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| LO50543 | Westburg | each | EUR 365.92 |
Rubeo™ Stain |
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| 21470010-1 | Glycomatrix | 200 mL | EUR 64.25 |
Rubeo™ Stain |
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| 21470010-2 | Glycomatrix | 500 mL | EUR 108.59 |
Eosin Y Stain |
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| 21770035-1 | Glycomatrix | 500 mL | EUR 29.36 |
Eosin Y Stain |
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| 21770035-2 | Glycomatrix | 1 L | EUR 48.17 |
No-Dye Stain |
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| 40140070-1 | Glycomatrix | 25 mL | EUR 53.99 |
No-Dye Stain |
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| 40140070-2 | Glycomatrix | 100 mL | EUR 125.36 |
Field’s Stain A |
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| S008-125ML | EWC Diagnostics | 1 unit | EUR 4.08 |
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Description: Field’s Stain A |
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Field’s Stain A |
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| S008-250ML | EWC Diagnostics | 1 unit | EUR 5.68 |
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Description: Field’s Stain A |
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Field’s Stain A |
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| S008-500ML | EWC Diagnostics | 1 unit | EUR 14.39 |
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Description: Field’s Stain A |
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Field’s Stain B |
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| S009-125ML | EWC Diagnostics | 1 unit | EUR 3.79 |
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Description: Field’s Stain B |
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Field’s Stain B |
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| S009-250ML | EWC Diagnostics | 1 unit | EUR 4.74 |
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Description: Field’s Stain B |
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Field’s Stain B |
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| S009-500ML | EWC Diagnostics | 1 unit | EUR 13.26 |
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Description: Field’s Stain B |
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Fite's Stain Kit |
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| FLS-1 | ScyTek Laboratories | 125 ml ea. | EUR 79.73 |
Fite's Stain Kit |
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| FLS-500 | ScyTek Laboratories | 500 ml ea. | EUR 196.72 |
SYBR DNA Stain |
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| PCR-273 | Jena Bioscience GmbH | 5 x 1,8ml | EUR 48.2 |
Iron Stain Kit |
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| IRN-1 | ScyTek Laboratories | 1 kit(s) | EUR 79.73 |
Iron Stain Kit |
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| IRN-125 | ScyTek Laboratories | 125 ml | EUR 84 |
Iron Stain Kit |
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| IRN-2 | ScyTek Laboratories | 100 Slides | EUR 41.14 |
Fite's Stain Kit |
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| K1425-125 | Biovision | each | EUR 444 |
Gram Stain Kit |
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| k1428-125 | Biovision | each | EUR 470.4 |
Gram Stain Kit |
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| k1428-30 | Biovision | each | EUR 314.4 |
Gram Stain Kit |
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| GSK-1 | ScyTek Laboratories | 125 ml ea. | EUR 60.43 |
Gram Stain Kit |
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| GSK-2 | ScyTek Laboratories | 30 ml ea. | EUR 33.42 |
Gram Stain Kit |
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| GSK-500 | ScyTek Laboratories | 500 ml ea. | EUR 203.14 |
Gel Stain Blue |
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| abx298033-100g | Abbexa | 100 µg | EUR 1062.5 |
Gel Stain Blue |
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| abx298033-20g | Abbexa | 20 µg | EUR 312.5 |
Gel Stain Blue |
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| abx298033-50g | Abbexa | 50 µg | EUR 400 |
Van Gieson Stain - 500ML |
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| VANG5H | Scientific Laboratory Supplies | 500ML | EUR 536.11 |
STAT-Q Goat DAB KIT for staining all Goat primary |
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| NB314KLGD-20 | Innovex | 20 ml kit | EUR 589 |
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Description: STAT-Q Goat DAB KIT for staining all Goat primary antibodies, 350 plus slides |
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Hi-Zinc Stain |
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| ML057-125ML | EWC Diagnostics | 1 unit | EUR 7.79 |
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Description: Hi-Zinc Stain |
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Hi-Zinc Stain |
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| ML057-250ML | EWC Diagnostics | 1 unit | EUR 14.82 |
|
Description: Hi-Zinc Stain |
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Albert’s Stain A |
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| S001-125ML | EWC Diagnostics | 1 unit | EUR 3.79 |
|
Description: Albert’s Stain A |
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Albert’s Stain A |
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| S001-500ML | EWC Diagnostics | 1 unit | EUR 13.26 |
|
Description: Albert’s Stain A |
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Albert’s Stain B |
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| S002-125ML | EWC Diagnostics | 1 unit | EUR 3.79 |
|
Description: Albert’s Stain B |
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Albert’s Stain B |
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| S002-500ML | EWC Diagnostics | 1 unit | EUR 13.26 |
|
Description: Albert’s Stain B |
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Fields Stain A |
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| F01383 | Pfaltz & Bauer | 25G | EUR 302.9 |
Fields Stain B |
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| F01385 | Pfaltz & Bauer | 25G | EUR 302.9 |
STAT-Q Rabbit DAB KIT for staining all Rabbit anti |
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| NB314KLRD-20 | Innovex | 20 ml kit | EUR 585 |
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Description: STAT-Q Rabbit DAB KIT for staining all Rabbit antibodies, 350 plus slides |
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STAT-Q Mouse Adsorbed DAB KIT for staining Rat ant |
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| NB314MAK-DAB | Innovex | 200-250 slides | EUR 695 |
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Description: STAT-Q Mouse Adsorbed DAB KIT for staining Rat antibodies-on-Mouse tissues 250 plus slide kit |
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STAT-Q Rat Adsorbed DAB KIT for staining Mouse ant |
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| NB314RAK-DAB | Innovex | 200-250 slides | EUR 695 |
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Description: STAT-Q Rat Adsorbed DAB KIT for staining Mouse antibodies-on-Rat tissues 250 plus slides kit |
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Copper Stain Kit |
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| CSK-1 | ScyTek Laboratories | 1 kit(s) | EUR 111.86 |
Silver Stain kit |
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| AR0171 | BosterBio | 1 kit (for 30 assays to stain the gel of 5 X8.5) | EUR 182.4 |
Geimsa Stain Kit |
|||
| K1426-30 | Biovision | each | EUR 346.8 |
Geimsa Stain Kit |
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| K1426-500 | Biovision | each | EUR 561.6 |
Orcein Stain Kit |
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| K1432-125 | Biovision | each | EUR 601.2 |
Orcein Stain Kit |
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| K1432-30 | Biovision | each | EUR 430.8 |
EvaGreenFluorescent DNA Stain (100µM) |
|||
| F253 | GeneOn | 1 ml | EUR 145.2 |
EvaGreenFluorescent DNA Stain (100µM) |
|||
| F253L | GeneOn | 5x1 ml | EUR 580.8 |
Ponceau-S Stain |
|||
| ML045-250ML | EWC Diagnostics | 1 unit | EUR 15.11 |
|
Description: Ponceau-S Stain |
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Leishman''s stain |
|||
| GT6256 | Glentham Life Sciences | 25g | EUR 137.69 |
Leishman''s stain |
|||
| GT6256-100 | Glentham Life Sciences | 100 | EUR 150.4 |
Leishman''s stain |
|||
| GT6256-25 | Glentham Life Sciences | 25 | EUR 55.4 |
Steiner Stain Kit |
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| K1435-125 | Biovision | each | EUR 535.2 |
Giemsa Stain RR88 |
|||
| RRSP54-3E-B | Atom Scientific | 3L Dispenser | EUR 35.96 |
Giemsa Stain RR88 |
|||
| RRSP54-5E-B | Atom Scientific | 5L Dispenser | EUR 46.58 |
Giemsa Stain RR88 |
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| RRSP54-D | Atom Scientific | 500ml | EUR 7.92 |
Giemsa Stain RR88 |
|||
| RRSP54-E | Atom Scientific | 1L | EUR 13.39 |
Giemsa Stain RR88 |
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| RRSP54-F | Atom Scientific | 2.5L | EUR 26.06 |
Giemsa Stain RR88 |
|||
| RRSP54-G | Atom Scientific | 5L | EUR 43.99 |
Giemsa Stain PR80 |
|||
| RRSP55-3E-B | Atom Scientific | 3L Dispenser | EUR 29.54 |
Giemsa Stain PR80 |
|||
| RRSP55-5E-G | Atom Scientific | 5L Dispenser | EUR 31.24 |
Giemsa Stain PR80 |
|||
| RRSP55-D | Atom Scientific | 500ml | EUR 9.06 |
Giemsa Stain PR80 |
|||
| RRSP55-E | Atom Scientific | 1L | EUR 12.49 |
Giemsa Stain PR80 |
|||
| RRSP55-F | Atom Scientific | 2.5L | EUR 22.73 |
Giemsa Stain PR80 |
|||
| RRSP55-G | Atom Scientific | 5L | EUR 29.54 |
Neissers Stain A |
|||
| RRSP104-D | Atom Scientific | 500ml | EUR 7.54 |
Neissers Stain A |
|||
| RRSP104-E | Atom Scientific | 1L | EUR 12.1 |
Neissers Stain A |
|||
| RRSP104-F | Atom Scientific | 2.5L | EUR 21.65 |
Neissers Stain B |
|||
| RRSP105-D | Atom Scientific | 500ml | EUR 7.54 |
Neissers Stain B |
|||
| RRSP105-E | Atom Scientific | 1L | EUR 12.1 |
Neissers Stain B |
|||
| RRSP105-F | Atom Scientific | 2.5L | EUR 21.65 |
Neissers Stain C |
|||
| RRSP106-D | Atom Scientific | 500ml | EUR 7.54 |
Neissers Stain C |
|||
| RRSP106-E | Atom Scientific | 1L | EUR 12.1 |
Neissers Stain C |
|||
| RRSP106-F | Atom Scientific | 2.5L | EUR 21.65 |
Neissers Stain D |
|||
| RRSP107-D | Atom Scientific | 500ml | EUR 7.54 |
Neissers Stain D |
|||
| RRSP107-E | Atom Scientific | 1L | EUR 12.1 |
Neissers Stain D |
|||
| RRSP107-F | Atom Scientific | 2.5L | EUR 21.65 |
Gel RedSafe Stain 10000X in water (Nucleic acid stain for Agarose Gels) |
|||
| S445 | GeneOn | 0,5 ml | EUR 86 |
GlycoGel Stain Kit |
|||
| 24693-1 | Polysciences Europe GmbH | 1kit | EUR 747 |
Grams iodine stain |
|||
| G05090 | Pfaltz & Bauer | 5G | EUR 216.28 |
Herovici's Stain Kit |
|||
| HSK-1 | ScyTek Laboratories | 1 kit(s) | EUR 76.22 |
May Grunwald Stain |
|||
| RRSP87-3E-B | Atom Scientific | 3L Dispenser | EUR 22.3 |
May Grunwald Stain |
|||
| RRSP87-D | Atom Scientific | 500ml | EUR 7.92 |
May Grunwald Stain |
|||
| RRSP87-E | Atom Scientific | 1L | EUR 11.32 |
May Grunwald Stain |
|||
| RRSP87-F | Atom Scientific | 2.5L | EUR 20.6 |
May Grunwald Stain |
|||
| RRSP87-G | Atom Scientific | 5L | EUR 22.3 |
May Grunwald Stain |
|||
| RRSP87-G-B | Atom Scientific | 5L Dispenser | EUR 28.25 |
Gel GreenSafe Stain 10000X in water (Nucleic acid stain for Agarose Gels) |
|||
| S440 | GeneOn | 0,5 ml | EUR 86 |
Reticulin Stain Kit |
|||
| 25094-250 | Polysciences Europe GmbH | 250ml | EUR 843 |