Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins.

Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins.

The nuclear magnetic resonance (NMR) spectroscopic data for organic macromolecules archived at the BioMagResBank (BMRB) present a wealthy useful resource of biophysical data at atomic decision. The NMR data archived in NMR-STAR ASCII format have been carried out in a relational database. However, it’s nonetheless pretty tough for customers to retrieve data from the NMR-STAR information or the relational database in affiliation with data from different organic databases.

To improve the interoperability of the BMRB database, we current a full conversion of BMRB entries to two commonplace structured data codecs, XML and RDF, as frequent open representations of the NMR-STAR data. Moreover, a SPARQL endpoint has been deployed. The described case research demonstrates {that a} easy question of the SPARQL endpoints of the BMRB, UniProt, and Online Mendelian Inheritance in Man (OMIM), can be utilized in NMR and structure-based evaluation of proteins mixed with data of single nucleotide polymorphisms (SNPs) and their phenotypes.We have developed BMRB/XML and BMRB/RDF and reveal their use in performing a federated SPARQL question linking the BMRB to different databases by way of commonplace semantic web applied sciences. This will facilitate data alternate throughout various data assets.

Research in natural sciences is mainly done by means of experiments. Some of those experiments such as spaceflight-dependent experiments are extremely laborious, complex and expensive. Hence, they often remain rare events with little chances of statistical tests and possibilities of repetition. In order to make each single event as valuable as possible, a sophisticated comparison of experimental data received with the hundreds of millions of computer-stored documents appears necessary.

We used results of an earlier study on proteome analysis of microgravity-exposed human thyroid cancer cells, selected twenty proteins which appeared gravity sensitive and investigated whether their change observed in cells under the loss of gravity could cause health problems in astronauts. Using network analysis via Knowledge Explorer (KE) we searched the literature for diseases related to one or more of the selected proteins.

Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins.
Publication of nuclear magnetic resonance experimental data with semantic web technology and the application thereof to biomedical research of proteins.

After using Linked Open Data (LOD) and other public resources to establish a comprehensive semantic knowledgebase around functional properties of the selected proteins, the collection’s network was used to query a set of databases for the proteins’ involvement in biosystems and human diseases. Finally, possible countermeasures could be proposed.

Immunohistochemistry Kit (OKRA00038)

OKRA00038 1 kit
EUR 966
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

Immunohistochemistry Kit (OKRA00039)

OKRA00039 1 kit
EUR 966
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

Immunohistochemistry Kit (OKRA00040)

OKRA00040 1 kit
EUR 966
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

Prediluted for Immunohistochemistry

RP-4003-04 7.0 ml
EUR 79.65

AIHS 620 Immunohistochemistry Stainer

AIHS620 -
EUR 38000

Tn, Prediluted for Immunohistochemistry

MM-1018-04 7.0 ml
EUR 120.05

Tg, Prediluted for Immunohistochemistry

MM-1021-04 7.0 ml
EUR 120.05

Tg, Prediluted for Immunohistochemistry

RP-4009-04 7.0 ml
EUR 79.65

K Prediluted for Immunohistochemistry

RP-4020-04 7.0 ml
EUR 79.65

EMA, Prediluted for Immunohistochemistry

MM-1001-04 7.0 ml
EUR 120.05

hCG, Prediluted for Immunohistochemistry

MM-1005-04 7.0 ml
EUR 120.05

ESA, Prediluted for Immunohistochemistry

MM-1014-04 7.0 ml
EUR 120.05

p53, Prediluted for Immunohistochemistry

MM-1015-04 7.0 ml
EUR 120.05

STn, Prediluted for Immunohistochemistry

MM-1019-04 7.0 ml
EUR 120.05

TSH, Prediluted for Immunohistochemistry

MM-1020-04 7.0 ml
EUR 120.05

CTP, Prediluted for Immunohistochemistry

RP-4004-04 7.0 ml
EUR 79.65

CEA, Prediluted for Immunohistochemistry

RP-4005-04 7.0 ml
EUR 79.65

PSA, Prediluted for Immunohistochemistry

RP-4010-04 7.0 ml
EUR 79.65

MBP, Prediluted for Immunohistochemistry

RP-4015-04 7.0 ml
EUR 79.65

AFP, Prediluted for Immunohistochemistry

RP-4017-04 7.0 ml
EUR 79.65

AαSM, Prediluted for Immunohistochemistry

MM-1004-04 7.0 ml
EUR 120.05

Brdu, Prediluted for Immunohistochemistry

MM-1006-04 7.0 ml
EUR 120.05

PCNA, Prediluted for Immunohistochemistry

MM-1016-04 7.0 ml
EUR 120.05

MUC2, Prediluted for Immunohistochemistry

RP-4013-04 7.0 ml
EUR 79.65

S100, Prediluted for Immunohistochemistry

RP-4014-04 7.0 ml
EUR 79.65

GFAP, Prediluted for Immunohistochemistry

RP-4016-04 7.0 ml
EUR 79.65

A1AT, Prediluted for Immunohistochemistry

RP-4019-04 7.0 ml
EUR 79.65

APO-BRDU-IHC IMMUNOHISTOCHEMISTRY KIT

GWB-Q00435 50 TESTS Ask for price

CK 19, Prediluted for Immunohistochemistry

MM-1002-04 7.0 ml
EUR 120.05

CK 18, Prediluted for Immunohistochemistry

MM-1009-04 7.0 ml
EUR 120.05

HBcAg, Prediluted for Immunohistochemistry

RP-4006-04 7.0 ml
EUR 79.65

HiPer® Immunohistochemistry Teaching Kit

HTI023-5PR 1 unit
EUR 144.14
Description: HiPer® Immunohistochemistry Teaching Kit

CK AE1, Prediluted for Immunohistochemistry

MM-1010-04 7.0 ml
EUR 120.05

CK AE3, Prediluted for Immunohistochemistry

MM-1011-04 7.0 ml
EUR 120.05

S 100, Prediluted for Immunohistochemistry

MM-1017-04 7.0 ml
EUR 120.05

Lambda, Prediluted for Immunohistochemistry

RP-4021-04 7.0 ml
EUR 79.65

Desmin, Prediluted for Immunohistochemistry

RP-4023-04 7.0 ml
EUR 79.65

Insulin Prediluted for Immunohistochemistry

RP-4012-04 7.0 ml
EUR 79.65

CK 8+18, Prediluted for Immunohistochemistry

MM-1007-04 7.0 ml
EUR 120.05

CK 10+13, Prediluted for Immunohistochemistry

MM-1008-04 7.0 ml
EUR 120.05

PR Immunohistochemistry control tissue array

PM2-PR each
EUR 78
Description: PR Immunohistochemistry control tissue array, including TNM and pathology grade of breast cancer, 11 cases/11 cores

Ferritin, Prediluted for Immunohistochemistry

RP-4001-04 7.0 ml
EUR 79.65

Vimentin, Prediluted for Immunohistochemistry

RP-4002-04 7.0 ml
EUR 79.65

Lysozyme, Prediluted for Immunohistochemistry

RP-4018-04 7.0 ml
EUR 79.65

Calcitonin, Prediluted for Immunohistochemistry

RP-4007-04 7.0 ml
EUR 79.65

Ubiquintin, Prediluted for Immunohistochemistry

RP-4011-04 7.0 ml
EUR 79.65

CK cocktail. Prediluted for Immunohistochemistry

MM-1012-04 7.0 ml
EUR 191.1

Transferrin, Prediluted for Immunohistochemistry

RP-4022-04 7.0 ml
EUR 79.65

Synaptophysin, Prediluted for Immunohistochemistry

RP-4008-04 7.0 ml
EUR 79.65

Sialosyl Le (a), Prediluted for Immunohistochemistry

MM-1003-04 7.0 ml
EUR 120.05

Normal Rabbit Control Serum (for immunohistochemistry)

NRS-IHC 500 μl
EUR 267.84

Myeloperoxidase (MPO), Prediluted for Immunohistochemistry

RP-4025-04 7.0 ml
EUR 79.65

Luteinizing Hormone (LH), Prediluted for Immunohistochemistry

RP-4024-04 7.0 ml
EUR 79.65

Cytokeratin AE1 and AE3, Prediluted for Immunohistochemistry

MM-1022-04 7.0 ml
EUR 136.15

Breast cancer with ER Immunohistochemistry control tissue array

PM2a-ER each
EUR 78
Description: Breast cancer with ER Immunohistochemistry control tissue array, including pathology grade, TNM, clinical stage and IHC results of ER/PR/Her-2/Ki67, 10 cases/10 cores, replacing PM2-ER

OOMB00003-10ML - Blocking Buffer for Immunocytochemistry and Immunohistochemistry

OOMB00003-10ML 10mL
EUR 79

OOMB00006-100ML - 10X Antigen Retrieval Solution pH 6.0 for Immunohistochemistry

OOMB00006-100ML 100mL
EUR 79

OOMB00007-100ML - 10X Antigen Retrieval Solution pH 9.0 for Immunohistochemistry

OOMB00007-100ML 100mL
EUR 79

OOMB00004-10ML - Permeabilization Buffer for Immunocytochemistry and Immunohistochemistry

OOMB00004-10ML 10mL
EUR 79

Epidermal Growth Factor Receptor, phosphorylated (Tyr1173) (erbB, EGFR), Immunohistochemistry Controls

MBS652639-5Slides 5Slides
EUR 460

Epidermal Growth Factor Receptor, phosphorylated (Tyr1173) (erbB, EGFR), Immunohistochemistry Controls

MBS652639-5x5Slides 5x5Slides
EUR 1920

MAP Kinase p44/42, phosphorylated (Thr202, Tyr204), Immunohistochemistry Controls (MAPK3/MAPK1, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activ

MBS652636-5Slides 5Slides
EUR 455

MAP Kinase p44/42, phosphorylated (Thr202, Tyr204), Immunohistochemistry Controls (MAPK3/MAPK1, Mitogen-activated Protein Kinase 1, MAP Kinase 1, MAPK 1, ERT1, Extracellular Signal-regulated Kinase 2, ERK-2, MAP Kinase Isoform p42, p42-MAPK, Mitogen-activ

MBS652636-5x5Slides 5x5Slides
EUR 1900

Super Plus High Sensitive and Rapid Immunohistochemical Kit (pH9.0)

MBS2567656-10mL 10mL
EUR 310

Super Plus High Sensitive and Rapid Immunohistochemical Kit (pH9.0)

MBS2567656-3mL 3mL
EUR 185

Super Plus High Sensitive and Rapid Immunohistochemical Kit (pH9.0)

MBS2567656-5x10mL 5x10mL
EUR 1370

Super Plus High Sensitive and Rapid Immunohistochemical Kit (pH6.0)

MBS2567657-10mL 10mL
EUR 310

Super Plus High Sensitive and Rapid Immunohistochemical Kit (pH6.0)

MBS2567657-3mL 3mL
EUR 185

Super Plus High Sensitive and Rapid Immunohistochemical Kit (pH6.0)

MBS2567657-5x10mL 5x10mL
EUR 1370

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH9.0)

E-IR-R220-10mL 10mL
EUR 325

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH9.0)

E-IR-R220-3mL 3mL
EUR 125

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH9.0)

E-IR-R220-each each Ask for price

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH6.0)

E-IR-R221-10mL 10mL
EUR 325

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH6.0)

E-IR-R221-3mL 3mL
EUR 125

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH6.0)

E-IR-R221-each each Ask for price

ImmunoHistozyme

AR-6547-01 15 ml
EUR 47.75

ImmunoHistozyme

AR-6547-02 100 ml
EUR 95.55

ImmunoHistoMount™

AR-6503-01 30 ml
EUR 60.05

ImmunoHistoMount™

AR-6503-02 100 ml
EUR 111.65

ImmunoHistoMount™

AR-6503-03 250 ml
EUR 203.35

ImmunoHistoMount™

AR-6503-05 1000 ml
EUR 556.5

DAB

40480000-1 5 g
EUR 27.68

DAB

40480000-2 10 g
EUR 48.92

DAB

40480000-3 25 g
EUR 99.35

DAB

HY-15912 500mg
EUR 129.6

DAB

MBS3845768-500mg 500mg
EUR 135

DAB

MBS3845768-5x500mg 5x500mg
EUR 600

Immuno HRP-DAB,ready to use IHC kit,anti-chicken IgY (H+L)

IH-8053-15 each reagent 15 ml
EUR 198.8

Immuno HRP-DAB,ready to use IHC kit,anti-chicken IgY (H+L)

IH-8053-50 each reagent 50 ml
EUR 357.7

DAB Tablet

D3225-020 20TB
EUR 170.4

DAB Tablet

D3225-050 50TB
EUR 295.2

DAB Tetrahydrochloride

40480004-1 5 g
EUR 38.33

DAB Tetrahydrochloride

40480004-2 10 g
EUR 53.07

DAB Tetrahydrochloride

40480004-3 25 g
EUR 124.38

DAB Enhancer for ampliying and darkening DAB stain

NB308 60 ml
EUR 385
Description: DAB Enhancer for ampliying and darkening DAB stains in IHC staining, 60 ml (Large volume)

DAB Enhancer for ampliying and darkening DAB stain

NB308-30 30 ml
EUR 245
Description: DAB Enhancer for ampliying and darkening DAB stains in IHC staining, 30 ml (Small volume)

Hematoxylin, Immuno/Histo Aqueous

AR-6520-01 15 ml
EUR 40.6

Hematoxylin, Immuno/Histo Aqueous

AR-6520-02 100 ml
EUR 47.75

Hematoxylin, Immuno/Histo Aqueous

AR-6520-03 250 ml
EUR 63.7

Hematoxylin, Immuno/Histo Aqueous

AR-6520-05 1000 ml
EUR 120.05

DAB-Am-32

D100040 500mg
EUR 11200
Description: 163611-04-9

IHC DAB solution

E22-NS000 120 T 
EUR 225

IHC DAB solution

MBS8579410-120Tests 120Tests
EUR 305

IHC DAB solution

MBS8579410-5x120Tests 5x120Tests
EUR 1480

DAB Chromogen Kit

abx097197-1Kit 1 Kit
EUR 326.4

DAB Substrate kit

30015-1 KT
EUR 111

DAB Detection Kit

E-IR-R101-1mL 1mL
EUR 35

DAB Detection Kit

E-IR-R101-3mL 3mL
EUR 50

DAB Detection Kit

E-IR-R101-6mL 6mL
EUR 85

DAB Detection Kit

E-IR-R101-each each Ask for price

DAB Chromogen, 4ml

NB314D 4 ml
EUR 295.2

DAB Chromogen Kit

abx097197-100l 100 µl
EUR 200

DAB Chromogen Kit

abx097197-1ml 1 ml Ask for price

DAB Chromogen Kit

abx097197-200l 200 µl Ask for price

DAB Substrate Kit

MBS7608280-INQUIRE INQUIRE Ask for price

DAB Chromogen Kit

MBS826735-5x60mL 5x60mL
EUR 745

DAB Chromogen Kit

MBS826735-60mL 60mL
EUR 185

DAB Substrate Buffer

ACC500 500 ml
EUR 18.01

DAB Substrate Buffer

ACC999 1000 ml
EUR 24.43

DAB Enhancer Solution

ACM030 30 ml
EUR 16.72

DAB (3,3'-Diaminobenzidine)

MBS639225-100g 100g
EUR 680

DAB (3,3'-Diaminobenzidine)

MBS639225-250g 250g
EUR 970

DAB (3,3'-Diaminobenzidine)

MBS639225-25g 25g
EUR 420

DAB (3,3'-Diaminobenzidine)

MBS639225-50g 50g
EUR 525

DAB (3,3'-Diaminobenzidine)

MBS639225-5x250g 5x250g
EUR 4210

DAB Chromogen Concentrate

D3226-002 20ml
EUR 193.2

DAB Chromogen Concentrate

D3226-005 50ml
EUR 400.8

DAB Chromogen Concentrate

ACB030 30 ml
EUR 55.28

DAB Chromogen Concentrate

ACB060 60 ml
EUR 92.57

DAB Chromogen Concentrate

ACB125 125 ml
EUR 156.85

DAB Chromogen Concentrate

ACB500 500 ml
EUR 498.84

DAB Chromogen Concentrate

ACB999 1000 ml
EUR 890.99

DAB Differentiating Solution

DDS500 500 ml
EUR 130.8

DAB Tetrahydrochloride, Hydrate

A2403-1G 1G
EUR 28.6
Description: Reagent

DAB Tetrahydrochloride, Hydrate

A2403-25G 25G
EUR 79.2
Description: Reagent

DAB Tetrahydrochloride, Hydrate

A2403-5G 5G
EUR 46.2
Description: Reagent

DAB Buffer, 10X For use with DAB Staining System for HRPO

MBS639268-100mL 100mL
EUR 320

DAB Buffer, 10X For use with DAB Staining System for HRPO

MBS639268-250mL 250mL
EUR 395

DAB Buffer, 10X For use with DAB Staining System for HRPO

MBS639268-500mL 500mL
EUR 500

DAB Buffer, 10X For use with DAB Staining System for HRPO

MBS639268-50mL 50mL
EUR 280

DAB Buffer, 10X For use with DAB Staining System for HRPO

MBS639268-5x500mL 5x500mL
EUR 2090

DAB Detection Kit (20×)

MBS2567141-1mL 1mL
EUR 120

DAB Detection Kit (20×)

MBS2567141-3mL 3mL
EUR 140

DAB Detection Kit (20×)

MBS2567141-5x6mL 5x6mL
EUR 675

DAB Detection Kit (20×)

MBS2567141-6mL 6mL
EUR 155

Immuno Fluoro Mount with DABCO™

AR-6518-01 20 ml
EUR 56.55

Immuno Fluoro Mount with DABCO™

AR-6518-02 100 ml
EUR 127.4

Sensitive DAB Stain Kit

PW023 5Preps, 5prep
EUR 82.97

DAB Two component liquid

AR-8206-01 100 ml
EUR 61.4

DAB Two component liquid

AR-8206-02 200 ml
EUR 104.3

DAB Two component liquid

AR-8206-05 1000 ml
EUR 331.8

DAB chromogenic kit(blue)

MBS176568-1Kit 1Kit
EUR 130

DAB chromogenic kit(blue)

MBS176568-5x1Kit 5x1Kit
EUR 435

DAB Substrate buffer, 70ml

NB314SB 70 ml
EUR 331.2

DAB Liquid Concentrate 50X

21530109-1 10 mL
EUR 92.44

DAB Liquid Concentrate 50X

21530109-2 25 mL
EUR 137.75

DAB Liquid Concentrate 50X

21530109-3 100 mL
EUR 388.67

DAB Liquid Concentrate 10X

21530113-1 100 mL
EUR 99.4

DAB Liquid Concentrate 10X

21530113-2 500 mL
EUR 259.7

DAB chromogenic kit(Yellow)

BC135-20ml 20ml
EUR 50

DAB chromogenic kit(yellow)

MBS176565-1Kit 1Kit
EUR 130

DAB chromogenic kit(yellow)

MBS176565-5x1Kit 5x1Kit
EUR 435

DAB (Post) Enhancing Solution

DES500 500 ml
EUR 30.85

DAB (Post) Enhancing Solution

DES999 1000 ml
EUR 47.58

DAB Chromogen/Substrate Kit

ACH500 500 Slides
EUR 28.28

DAB Substrate (High Contrast)

ACU250 250 ml
EUR 28.28

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